New and traditional serum markers of bone metabolism in the detection of skeletal metastases
New and traditional serum markers of bone metabolism in the detection of skeletal metastases
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DOI：
10.1016/0009-9120(95)02001-2
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发表时间：
1996-02-01
影响因子：
2.8
通讯作者：
Sciacovelli, L
中科院分区：
文献类型：
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作者：
Plebani, M;Bernardi, D;Sciacovelli, L
目的：评价成骨细胞和破骨细胞活性的“新的”和“传统的”标志物在骨转移患者中的作用。设计和方法：我们的研究包括40名有临床、放射和核素证据的骨转移患者和40名年龄匹配的健康受试者。在所有样本中，通过测量总碱性磷酸酶(ALP)、抗酒石酸酸性磷酸酶(TRACP)活性和骨钙素(BGP)浓度来评估传统标志物。通过检测骨碱性磷酸酶同工酶(ALP-B)活性、I型前胶原羧基末端前肽(PICP)和I型胶原羧基末端多肽(ICTP)浓度来评价新的骨生化指标。结果：ICTP的诊断效率最高(0.94)，其次是总ALP(0.90)、ALP-B(0.80)和TRACP(0.76)。相反，BGP和PICP的检测效率很低(分别为0.64和0.60)。结论：我们的结果证实了ALP-B和ICTP等新的血清标志物在骨转移检测中的应用。
Objectives: The evaluation of ''new'' and ''traditional'' markers of osteoblastic and osteoclastic activity, in patients with bone metastases.Design and Methods: Our series consist of 40 patients with clinical, radiological, and scintigraphic evidence of bone metastases, and 40 age-matched healthy subjects. In all samples, traditional markers were evaluated by measuring total alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TrACP) activity, and osteocalcin (BGP) concentration. To assess new biochemical bone markers, bone isoenzyme of alkaline phosphatase (ALP-B) activity, carboxyterminal propeptide of type I procollagen (PICP), and carboxyterminal telopeptide of type I collagen (ICTP) concentrations were measured.Results: Our findings showed that the best diagnostic efficiency is provided by ICTP (0.94) followed by total ALP (0.90), ALP-B (0.80), and TrACP (0.76). The efficiency of BGP and PICP was, instead, very low (0.64 and 0.60, respectively).Conclusion: Our results confirm the utility of the new serum markers such as ALP-B and ICTP assays in detecting bone metastases.