Platelets and platelet-derived microparticles in vascular inflammatory disease.
Platelets and platelet-derived microparticles in vascular inflammatory disease.
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DOI：
10.2174/187152810793938008
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
E. Vasina;J. Heemskerk;C. Weber;R. Koenen
中科院分区：
文献类型：
--
作者：
E. Vasina;J. Heemskerk;C. Weber;R. Koenen
动脉粥样硬化及其随后的动脉粥样硬化血栓形成是大动脉的炎症性疾病，具有高死亡率和发病率。血细胞和动脉血管壁之间的相互作用被认为决定了动脉粥样硬化斑块和血栓并发症的进展。越来越多的证据表明，活化的血小板和血小板衍生微粒通过与白细胞、内皮细胞和平滑肌细胞接触，在该疾病过程中发挥重要作用。本文概述了新近描述的血小板和微粒与心血管系统其他细胞通过直接接触或介质释放的相互作用。这些相互作用的可能意义将在血管炎症的背景下进行讨论。
Atherosclerosis with ensuing atherothrombosis is an inflammatory disease of the large arteries with high mortality and morbidity. Interactions between blood cells and the arterial vessel wall are considered to determine the progression of atherosclerotic plaques and the thrombotic complications. There is increasing evidence for important roles of activated platelets and platelet-derived microparticles in this disease process by contact with leukocytes, endothelial cells and smooth muscle cells. This paper gives an overview of newly described interactions of platelets and microparticles with other cells of the cardiovascular system via direct contact or via mediator release. The possible significance of these interactions is discussed within the context of vascular inflammation.