Predictors of Adherence to Antiretroviral Therapy among HIV/AIDS Patients in the Upper West Region of Ghana.
Predictors of Adherence to Antiretroviral Therapy among HIV/AIDS Patients in the Upper West Region of Ghana.
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DOI：
10.1155/2013/873939
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Fofie CO
中科院分区：
文献类型：
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作者：
Obirikorang C;Selleh PK;Abledu JK;Fofie CO
背景抗逆转录病毒疗法干预措施的有效性只有在最大程度的坚持下才能实现。有效抑制艾滋病毒/艾滋病病毒需要>95%的近乎完美的坚持水平。本研究的主要目的是确定促进艾滋病毒/艾滋病患者坚持抗逆转录病毒治疗的社会人口和社会经济因素。方法.这项描述性横断面研究于2013年3月至5月在华盛顿州上西区医院进行。共201例确诊的HIV 1血清阳性受试者（平均年龄36.6 ± 9.9岁）接受抗逆转录病毒治疗使用结构式问卷进行了访谈。使用GraphPad Prism版本5分析收集的数据。对于所有统计分析，P值<0.05被认为具有统计学显著性。结果总体终生依从性为62.2%，而最近6个月、最近3个月、最近一个月和最近一周的药物依从性分别为73.6%、87.1%、91.0%和86.0%。该研究揭示了坚持ART和免疫成功之间的正相关，不坚持增加免疫失败的风险（OR（95% CI）：9.2（3.2-26.9））。单因素Logistic回归分析的数据显示，其他疾病和药物的副作用与坚持ART呈负相关，而自我感觉健康，家庭的支持，定期随访呈正相关，坚持ART。定期参加随访和家庭支持是100%终身服药依从性的重要因素。为接受抗逆转录病毒治疗的病人提供关于坚持治疗的有效咨询，对于在加纳实现抗逆转录病毒治疗方案的目的至关重要。
Background. The effectiveness of ART interventions is only realized in maximal levels of adherence. A near perfect adherence level of >95% is required for the effective suppression of HIV/AIDS virus. The main objective of this study was to identify the sociodemographic and socioeconomic factors that facilitate adherence to antiretroviral therapy among HIV/AIDS patients. Methods. This descriptive cross-sectional study was conducted between March and May 2013 at the Upper West Regional Hospital, Wa. A total of 201 confirmed HIV 1 seropositive subjects (mean age 36.6 ± 9.9 years) receiving antiretroviral therapy were interviewed using a structured questionnaire. The collected data was analyzed using GraphPad Prism version 5. A P value of <0.05 was considered statistically significant for all statistical analyses. Results. Overall lifetime adherence was found to be 62.2% while medication adherence in the last six months, last three months, last month, and last week were 73.6%, 87.1%, 91.0%, and 86.0%, respectively. The study revealed a positive association between adherence to ART and immunological success, with nonadherence increasing the risk (OR (95% CI): 9.2 (3.2–26.9)) of immunological failure. Univariate logistic regression analysis of the data showed that other ailments and side effects of drug were negatively associated with adherence to ART whereas self-perceived wellness, family support, and regular followup were positively associated with adherence to ART. Conclusion. Regular attendance at followup and family support are vital factors for 100% lifetime medication adherence. Effective counseling sessions on adherence for patients on antiretroviral therapy are paramount for the realization of the purpose of antiretroviral therapy programmes in Ghana.