Renal effects of drugs that inhibit prostaglandin synthesis.
Renal effects of drugs that inhibit prostaglandin synthesis.
复制标题
抑制前列腺素合成的药物对肾脏的影响。
DOI：
10.1038/ki.1980.179
复制
发表时间：
1980
影响因子：
19.6
通讯作者：
Zambraski,EJ
中科院分区：
文献类型：
--
作者：
Dunn,MJ;Zambraski,EJ
在大多数（如果不是全部）身体器官中抑制前列腺素合成的前列腺素药物在临床上有广泛的应用。这些药物的大部分疗效取决于炎症部位前列腺素合成的减少。毫不奇怪，这些药物的许多副作用是继发于脑、脉管系统、胃、肺和肾中前列腺素合成减少。在这篇综述中，我们将重点关注这些化合物对肾功能的影响，特别强调肾素分泌，控制肾血流量（RBF）和肾小球滤过率（GFR）。为了描述前列腺素抑制的肾脏后果，我们将简要回顾前列腺素合成的生物化学和已知的主要生理作用的前列腺素在肾脏。
There is extensive, clinical use of antiinflammatory drugs that inhibit prostaglandin synthesis in most, if not all, organs in the body. Much of the therapeutic efficacy of these agents depends on a reduction of prostaglandin synthesis at the site of inflammation. Not surprisingly, many of the side-effects of these drugs are secondary to decreased prostaglandin synthesis in brain, vasculature, stomach, lung, and kidney. In this review, we will focus attention on the effects of these antiinflammatory compounds on renal function, with particular emphasis on renin secretion, control of renal blood flow (RBF), and glomerular filtration rate (GFR). To describe these renal consequences of prostaglandin inhibition, we will briefly review the biochemistry of prostaglandin synthesis and the major known physiologic actions of prostaglandins in the kidney.