Compromised dynamic cerebral autoregulation in patients with generalized anxiety disorder: a study using transfer function analysis.
Compromised dynamic cerebral autoregulation in patients with generalized anxiety disorder: a study using transfer function analysis.
复制标题
广泛性焦虑症患者的动态大脑自动调节受损：一项使用传递函数分析的研究。
DOI：
10.1186/s12888-018-1713-z
复制
发表时间：
2018-06-01
期刊：
影响因子：
4.4
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Guo ZN;Lv S;Liu J;Wang Z;Jin H;Qiu Q;Sun X;Yang Y
广泛性焦虑症（GAD）患者常表现出多种神经系统症状，但其发病机制尚不清楚。目的分析广泛性焦虑症患者动态脑自动调节（dCA）的特点。本研究入组了诊断为GAD的患者（年龄≥18岁）。招募医学和精神健康的志愿者作为对照。受试者接受汉密尔顿焦虑量表（HAMA）和17项汉密尔顿抑郁量表（HAMD）评定。同时记录每例受试者的无创连续动脉血压和双侧大脑中动脉血流速度。传递函数分析用于推导自动调节参数，包括相位差、增益和相干函数。共纳入57例GAD患者和40例健康志愿者。我们发现GAD患者的相位差值明显受损。斯皮尔曼相关分析显示，相位差值与HAMA评分、HAMD评分呈负相关。多元线性回归分析中，GAD与相位差值呈负相关，而年龄与相位差值呈正相关。结果表明，广泛性焦虑症患者的dCA受损，并与焦虑评分呈负相关。改善dCA可能是治疗GAD患者神经系统症状的潜在治疗方法。
Patients with generalized anxiety disorder (GAD) usually present with various neurological symptoms, but the mechanisms remain unclear. We aimed to analyze the characteristics of dynamic cerebral autoregulation (dCA) in patients with GAD. Patients (aged ≥18 years) who were diagnosed with GAD were enrolled in this study. Medically and psychiatrically healthy volunteers were recruited as controls. Subjects received the Hamilton Rating Scale for Anxiety (HAMA) and 17-item Hamilton Depression Rating Scale (HAMD) evaluation. Noninvasive continuous arterial blood pressure and bilateral middle cerebral artery blood flow velocity were recorded simultaneously from each subject. Transfer function analysis was used to derive the autoregulatory parameters, including phase difference, gain, and coherence function. A total of 57 patients with GAD and 40 healthy volunteers were enrolled. We found that the phase difference values were significantly compromised in patients with GAD. In the Spearman correlation analysis, the phase difference values were negatively correlated with the HAMA scores and the HAMD scores. In the multiple linear regression analysis, GAD is negatively correlated with the phase difference values, whereas age is positively correlated with the phase difference values. Our results suggested that the dCA was compromised in patients with GAD and negatively correlated with the score of anxiety. Improving the dCA may be a potential therapeutic method for treating the neurological symptoms of GAD patients.
登录
查看更多内容
影响因子：
3.7
作者：
Dieleman, Gwendolyn C.;Huizink, Anja C.;Verhulst, Frank C.
通讯作者：
Verhulst, Frank C.
影响因子：
4.1
作者：
Kalk, N. J.;Melichar, J.;Nutt, D. J.
通讯作者：
Nutt, D. J.
影响因子：
2.9
作者：
Chi, Nai-Fang;Ku, Hsiao-Lun;Hu, Chaur-Jong
通讯作者：
Hu, Chaur-Jong
DOI：
10.1111/jon.12019
发表时间：
2014-07
期刊：
Journal of neuroimaging : official journal of the American Society of Neuroimaging
影响因子：
--
作者：
Ortega-Gutierrez S;Petersen N;Masurkar A;Reccius A;Huang A;Li M;Choi JH;Marshall RS
通讯作者：
Marshall RS
影响因子：
10.6
作者：
Makovac, Elena;Meeten, Frances;Ottaviani, Cristina
通讯作者：
Ottaviani, Cristina