Validation of the Spanish Version of the Addenbrooke's Cognitive Examination-Revised (ACE-R)
Validation of the Spanish Version of the Addenbrooke's Cognitive Examination-Revised (ACE-R)
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DOI：
10.1016/j.nrl.2010.10.013
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发表时间：
2011-07-01
期刊：
影响因子：
3.9
通讯作者：
Manes, F.
中科院分区：
文献类型：
--
作者：
Torralva, T.;Roca, M.;Manes, F.
背景：阿登布鲁克认知测验修订版(ACE-R)是早期简短筛查测验的改进版本，已在英语中得到验证，对检测认知功能障碍具有很高的敏感性和特异性。本研究的目的是在阿根廷人群中验证西班牙版的ACE-R。方法：使用ACE-R对一组阿尔茨海默病(AD)患者和行为变异型额颞叶痴呆(BvFTD)患者进行年龄、性别和教育年限与健康对照的配对评估。采用临床痴呆评定量表(CDR)评定痴呆程度。结果：ACE-R量表的内部信度良好(Cronbach‘sα=0.89)。由总ACE-R和CDR之间的相关性确定的同时效度显著(P<；.001)，评分者间信度极好(Cohen‘s kappa=0.98)。对照组在ACE-R的大多数亚域上显著优于AD和bvFTD患者，痴呆组之间存在显著差异。以85分为界，诊断痴呆的敏感性为97.5%，特异性为88.5%，似然比为99.3。结论：西班牙文版ACE-R是一种简明可靠的早期认知功能障碍筛查工具，可区分bvFTD和AD。(C)2010年西班牙神经症协会。由Elsevier Espana，S.L.出版，版权所有。
Background: The Addenbrooke's Cognitive Examination Revised (ACE-R) is an improved version of the earlier brief screening test which has been validated in English with high sensitivity and specificity to detect cognitive dysfunction. The aim of this study was to validate the Spanish version of the ACE-R in an Argentine population.Methods: A group of patients with Alzheimer Disease (AD) and patients with behavioural variant Frontotemporal Dementia (bvFTD) paired by age, sex, and years of education with healthy controls were assessed using the ACE-R. Stage of dementia was measured with the Clinical Dementia Rating Scale (CDR). The English version of the ACE-R was first translated into Spanish and then back-translated into English by two blind independent experts.Results: Internal reliability was very good (Cronbach's alpha = 0.89). Concurrent validity, determined by the correlation between total ACE-R and CDR was significant (P < .001) and inter-rater reliability was excellent (Cohen's kappa = 0.98). Controls significantly outperformed AD and bvFTD patients on most subdomains of the ACE-R, with significant differences between the dementia groups. With a cut-off score of 85 points, sensitivity was 97.5% and specificity was 88.5%, with a likelihood ratio of 99.3 for the detection of dementia. The ACE-R showed higher sensitivity than the MMSE for the detection of dementia.Conclusions: The Spanish version of the ACE-R is a brief yet reliable screening tool for the detection of early cognitive impairment and has shown to discriminate between bvFTD and AD. (C) 2010 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.