Relationship Among Corneal Stiffness, Thickness, and Biomechanical Parameters Measured by Corvis ST, Pentacam and ORA in Keratoconus
Relationship Among Corneal Stiffness, Thickness, and Biomechanical Parameters Measured by Corvis ST, Pentacam and ORA in Keratoconus
复制标题
Corvis ST、Pentacam 和 ORA 测量的圆锥角膜角膜硬度、厚度和生物力学参数之间的关系
DOI：
10.3389/fphys.2019.00740
复制
发表时间：
2019-06-13
影响因子：
4
通讯作者：
Zhou, Xingtao
中科院分区：
文献类型：
--
作者：
Zhao, Yu;Shen, Yang;Zhou, Xingtao
目的：评估角膜结构中的角膜刚度，厚度和生物力学参数之间的关系。Setting：中国上海福丹大学的Eent医院。招募了44名患者。根据最陡峭的K读（KMAX），将眼睛分为三组：温和（31眼； 42.1-54.5d）；中度（27眼，55.0-61.6d）;和严重的（17眼，65.2-94.5d）。将31个健康受试者招募为对照组。所有患者同时接受了Corvis St，Pentacam和ORA检查。使用Corvis ST评估刚度参数A1（SP-A1）和其他动态参数。使用Pentacam获得了Kmax和最薄的角膜厚度（TCT）。使用ORA测量角膜抗性因子（CRF）和角膜滞后（CH）。相关性分析用于研究变量之间的关联。结果：与对照组相比，在不同阶段的圆锥角膜不同阶段的SP-A1降低（P
Purpose To assess the relationship among corneal stiffness, thickness, and biomechanical parameters in keratoconus. Setting The EENT Hospital of Fudan University, Shanghai, China. Design Comparative study. Methods In this cross-sectional prospective study, 75 keratoconic eyes of 44 patients were recruited. Eyes were divided three groups according to the steepest K-readings (Kmax): mild (31 eyes; 42.1–54.5D); moderate (27 eyes, 55.0–61.6D); and severe (17 eyes, 65.2–94.5D). Thirty-one healthy subjects were recruited as the control group. All patients underwent Corvis ST, Pentacam and ORA examinations at the same time. Stiffness parameter A1 (SP-A1) and other dynamic parameters were assessed using the Corvis ST. Kmax and thinnest corneal thickness (TCT) was obtained using the Pentacam. Corneal resistance factor (CRF) and corneal hysteresis (CH) were measured using the ORA. Analysis of correlation was applied to investigate the association between variables. Results There was a decrease in SP-A1 in different stages of keratoconus compared with controls (P ≤ 0.001): with increasing severity, the value of SP-A1 became smaller (P < 0.05). A statistically significant linear relationship was noted between SP-A1 and TCT in each subgroup of keratoconus (P ≤ 0.001). In all three groups, SP-A1 was found to be positively correlated with first applanation time (P < 0.01), while negatively correlated with deformation amplitude (P < 0.05). Analysis of SP-A1 with regard to CRF and CH indicated statistically positive correlation in keratoconus (P < 0.05). Conclusion Significant decreases in corneal stiffness were noted in kerotoconic eyes compared with normal eyes. The stiffness parameter could be a valuable clinical tool enables biomechanically track progression with keratoconus. Synopsis Our study found that corneal thinning and biomechanical decreasing synchronize with one another throughout the progression of the keratoconus, and SP-A1 could be a potential biomarker evaluating disease progression.