1 Year HIIT and Omega-3 Fatty Acids to Improve Cardiometabolic Risk in Stage-A Heart Failure
1 Year HIIT and Omega-3 Fatty Acids to Improve Cardiometabolic Risk in Stage-A Heart Failure
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1 年 HIIT 和 Omega-3 脂肪酸可改善 A 期心力衰竭的心脏代谢风险
DOI：
10.1016/j.jchf.2022.01.004
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Sarma S.
中科院分区：
文献类型：
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作者：
Hearon CM Jr;Dias KA;MacNamara JP;Hieda M;Mantha Y;Harada R;Samels M;Morris M;Szczepaniak LS;Levine BD;Sarma S.
本研究旨在确定1年的高强度间歇训练(HIIT)和补充omega-3脂肪酸(n-3 FA)是否能改善心力衰竭(心衰)高危肥胖中年人(A期)的体能、心血管结构/功能和身体成分。0.6pg/mL2 kg内脏脂肪)随机分为1年的HIIT运动组或注意力控制组，分别给予n-3FA(1.6g/d欧米茄-3-酸乙酯)或安慰剂(每日1.6g橄榄油)。结果56名志愿者完成了干预，包括峰值摄氧量、左心室质量、左心室容量、心肌甘油三酯含量(磁共振波谱)、动脉僵硬/功能(中心脉搏波速度；增强指数)和身体成分(双X线骨密度扫描)。HIIT对内脏脂肪和心肌甘油三酯含量无明显影响(Δ：-2.63 kg，95%CI：-4.08to-0.46，P=0.018)。HIIT提高了24%的∼运动能力(Δ：4.46mL/kg/min，95%CI：3.18~5.56；P<；0.0001)，增加了LV质量(Δ：9.40g，95%CI：4.36~14.44；P<；0.001)，以及容量(Δ：12.33mL，95%CI：5.61~19.05；P<；0.001)，增强指数降低(Δ：-4.81%，95%CI：-8.63~-0.98；P=0.009)。结论一年的HIIT可改善A期心力衰竭患者的运动能力、心血管结构/功能和肥胖程度，且不存在n-3FA的独立或相加作用。(改善舒张期功能障碍患者的代谢健康[MTG]；NCT03448185)
ObjectivesThis study aims to determine whether 1 year of high-intensity interval training (HIIT) and omega-3 fatty acid (n-3 FA) supplementation would improve fitness, cardiovascular structure/function, and body composition in obese middle-aged adults at high-risk of heart failure (HF) (stage A).BackgroundIt is unclear if intensive lifestyle interventions begun in stage A HF can improve key cardiovascular and metabolic risk factors.MethodsHigh-risk obese adults (n = 80; age 40 to 55 years; N-terminal pro–B-type natriuretic peptide >40 pg/mL or high-sensitivity cardiac troponin T >0.6 pg/mL; visceral fat >2 kg) were randomized to 1 year of HIIT exercise or attention control, with n-3 FA (1.6 g/daily omega-3-acid ethyl esters) or placebo supplementation (olive oil 1.6 g daily). Outcome variables were exercise capacity quantified as peak oxygen uptake (), left ventricular (LV) mass, LV volume, myocardial triglyceride content (magnetic resonance spectroscopy), arterial stiffness/function (central pulsed-wave velocity; augmentation index), and body composition (dual x-ray absorptiometry scan).ResultsFifty-six volunteers completed the intervention. There was no detectible effect of HIIT on visceral fat or myocardial triglyceride content despite a reduction in total adiposity (Δ: -2.63 kg, 95% CI: -4.08 to -0.46,P= 0.018). HIIT improved exercise capacity by ∼24% (Δ: 4.46 mL/kg per minute, 95% CI: 3.18 to 5.56;P< 0.0001), increased LV mass (Δ: 9.40 g, 95% CI: 4.36 to 14.44;P< 0.001), and volume (Δ: 12.33 mL, 95 % CI: 5.61 to 19.05;P< 0.001) and reduced augmentation index (Δ: -4.81%, 95% CI: -8.63 to -0.98;P= 0.009). There was no independent or interaction effect of n-3 FA on any outcome.ConclusionsOne-year HIIT improved exercise capacity, cardiovascular structure/function, and adiposity in stage A HF with no independent or additive effect of n-3 FA administration. (Improving Metabolic Health in Patients With Diastolic Dysfunction [MTG]; NCT03448185)