Association of lead-exposure risk and family income with childhood brain outcomes
Association of lead-exposure risk and family income with childhood brain outcomes
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DOI：
10.1038/s41591-019-0713-y
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发表时间：
2020-01-01
期刊：
影响因子：
82.9
通讯作者：
Sowell, Elizabeth R.
中科院分区：
文献类型：
--
作者：
Marshall, Andrew T.;Betts, Samantha;Sowell, Elizabeth R.
对青少年大脑认知发展研究的数据的横断面分析表明，与有高收入的家庭相比，低收入家庭的儿童的认知障碍风险增加了与高铅暴露风险相关的风险。社会经济因素会影响大脑发展和结构，但是大多数研究都忽略了损害发育的神经毒性损伤，例如铅暴露。儿童期铅暴露会以最低的可测量浓度影响认知发展，但对其对儿童期间大脑发育的影响知之甚少。我们检查了9,712个9岁和10岁儿童的大脑结构，认知，地理编码措施和社会人口统计学特征的横断面关联。在这里，我们显示了来自低收入家庭和高收入家庭的儿童中的高领域人口普查区生活的更强的负面联系。随着暴露风险的增加，来自低收入家庭的儿童表现出较低的认知测试评分，较小的皮质体积和较小的皮质表面积。减少与铅暴露风险相关的环境侮辱可能会给儿童带来更多的环境逆境，进一步了解与高铅暴露风险相关的因素，对于改善儿童的这种结果至关重要。
Cross-sectional analysis of data from the Adolescent Brain Cognitive Development Study shows that children from families with low income are at increased risk of cognitive impairment associated with high lead-exposure risk when compared with children from families with high income.Socioeconomic factors influence brain development and structure, but most studies have overlooked neurotoxic insults that impair development, such as lead exposure. Childhood lead exposure affects cognitive development at the lowest measurable concentrations, but little is known about its impact on brain development during childhood. We examined cross-sectional associations among brain structure, cognition, geocoded measures of the risk of lead exposure and sociodemographic characteristics in 9,712 9- and 10-year-old children. Here we show stronger negative associations of living in high-lead-risk census tracts in children from lower- versus higher-income families. With increasing risk of exposure, children from lower-income families exhibited lower cognitive test scores, smaller cortical volume and smaller cortical surface area. Reducing environmental insults associated with lead-exposure risk might confer greater benefit to children experiencing more environmental adversity, and further understanding of the factors associated with high lead-exposure risk will be critical for improving such outcomes in children.