A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.
A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.
复制标题
DOI：
10.3390/md13084594
复制
发表时间：
2015-07-23
期刊：
影响因子：
5.4
通讯作者：
Liu CH
中科院分区：
文献类型：
--
作者：
Wang YT;Xue YR;Liu CH
深海真菌是指生活在海洋和海底1000 m以下沉积物中的真菌，由于其结构和功能的多样性，已成为工业、农业和营养保健品化合物的重要来源。自从大约50年前在大西洋4450米深处进行了第一次深海真菌研究以来，已经根据培养依赖方法报道了数百种深海真菌分离株。迄今为止，文献中已记录了180多种来自深海真菌的生物活性次级代谢产物。这些包括具有抗癌、抗微生物、抗真菌、抗原生动物和抗病毒活性的化合物。本文就这些代谢产物的结构和生物活性进行综述，以期为新药开发提供帮助。
Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.