On the Control of Gene Expression
On the Control of Gene Expression
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论基因表达的控制
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
K. Rudd
中科院分区：
文献类型：
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作者：
H. Westerhoff;J. Koster;M. Workum;K. Rudd
代谢途径的控制理论已经相当完整（Kacser & Porteous，1987; Kell & Westerhoff，1986; Westerhoff &货车Dam，1987; Wester-hoff，1989 ab;也可参见本书的许多章节，特别是Porteous的第3章）。然而，它讨论的是单一级别的控制，即，代谢途径，没有考虑基因表达的变异性明确考虑。在代谢控制理论中，蛋白质浓度只能通过干预来重置。这种类型的控制分析对于理解代谢控制的原理以及理解太快或在太有限的代谢系统中涉及基因表达变化的代谢变化很有用。由于基因表达的变化是普遍存在的，并明确涉及代谢调控，它是有趣的，看看代谢控制的原则如何变化，如果可变基因表达被考虑在内。在这一章中，我们提出了第一次尝试扩展代谢控制理论的可变基因表达。我们还讨论了两个实验的情况下，我们已经分析了这种控制，并明确规定不同于控制。
The control theory of metabolic pathways has become fairly complete (reviewed in Kacser & Porteous, 1987; Kell & Westerhoff, 1986; Westerhoff & Van Dam, 1987; Wester-hoff, 1989ab; see also numerous chapters in this book, especially Chapter 3 by Porteous). However, it discusses control at a single level, i.e., that of metabolic pathways, without taking the variability of gene expression explicitly into account. In metabolic control theory, protein concentrations can only be reset by interventions. This type of control analysis is useful for understanding principles of metabolic control, and for understanding metabolic changes that are too quick or in too limited a metabolic system to involve changes in gene expression. Because variations in gene expression are ubiquitous and clearly implicated in metabolic regulation, it is of interest to see how the principles of metabolic control change if variable gene expression is taken into account. In this chapter we present a first attempt to extend metabolic control theory to variable gene expression. We also discuss two experimental situations in which we have analysed such control and make explicit where regulation differs from control.