Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases.
Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases.
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DOI：
10.3892/etm.2012.612
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发表时间：
2012-09
影响因子：
2.7
通讯作者：
Park SJ
中科院分区：
文献类型：
--
作者：
Bae GS;Park KC;Koo BS;Jo IJ;Choi SB;Song HJ;Park SJ
以前，我们报道了甘松（NJ）减轻雨蛙素诱导的轻度急性胰腺炎（AP）。在本研究中，我们研究了NJ改善由胆碱缺乏饮食补充乙醇（CDE）诱导的重症急性胰腺炎（SAP）的能力。在CDE给药期间，通过水随意经口给予NJ浸提液。三天后，CDE被正常饮食取代。正常喂养4天后，处死小鼠，取血液和胰腺用于进一步研究。NJ治疗减少SAP诱导的胰腺损伤，如组织学所示。NJ治疗还抑制中性粒细胞浸润到胰腺中。NJ还抑制SAP攻击胰腺中消化酶和细胞因子的分泌，并抑制有丝分裂原活化蛋白激酶（MAPK）的活化。这些数据表明，新泽西州通过使MAPKs失活来防止CDE诱导的SAP中的胰腺损伤。
Previously, we reported that Nardostachys jatamansi (NJ) attenuated cerulein-induced mild acute pancreatitis (AP). In the present study, we investigated the ability of NJ to ameliorate severe acute pancreatitis (SAP) induced by a choline-deficient diet supplemented with ethionine (CDE). An NJ extract was orally administered ad libitum via the water during administration of the CDE. After three days, the CDE was replaced with a normal diet. After four days of normal feeding the mice were sacrificed and the blood and pancreas were obtained for further investigation. NJ treatment reduced SAP-induced pancreatic damage, as shown by histology. NJ treatment also inhibited neutrophil infiltration into the pancreas. NJ also inhibited the secretion of digestive enzymes and cytokine production, and inhibited the activation of mitogen-activated protein kinases (MAPKs) in the SAP-challenged pancreas. These data suggest that NJ protects against pancreatic injury in CDE-induced SAP by deactivating MAPKs.
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DOI：
10.1152/ajpgi.00210.2010
发表时间：
2011-10-01
影响因子：
4.5
作者：
Kim, Tae-Hyeon;Bae, Gi-Sang;Park, Sung-Joo
通讯作者：
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影响因子：
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影响因子：
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作者：
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
8.8
作者：
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通讯作者：
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