Differential contribution of frontal and temporal cortices to auditory change detection:: fMRI and ERP results
Differential contribution of frontal and temporal cortices to auditory change detection:: fMRI and ERP results
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DOI：
10.1006/nimg.2001.0970
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发表时间：
2002-01-01
期刊：
影响因子：
5.7
通讯作者：
Schröger, E
中科院分区：
文献类型：
--
作者：
Opitz, B;Rinne, T;Schröger, E
本研究探讨了颞叶和额叶在听觉变化检测中的功能作用。先前的事件相关电位（ERP）研究表明，失配负性（MMN）反映了颞额叶网络的参与，促进听觉变化检测过程和非自愿注意转换的启动。在本研究中，向参与者呈现重复的频谱丰富的声音。刺激序列中嵌入了小（10% 变化）、中（30 10 变化）或大（100% 变化）幅度的不频繁变化。在随后的治疗中对同一受试者进行了 ERP 和 fMRI 测量。仅在大和中型异常者中观察到双侧颞上回（STG）和右额下回盖部分的显着血流动力学激活。 ERPs 显示，小偏差在安静时会引发 MMN，但在记录的 MR 背景噪声下不会引起 MMN，这表明在 fMRI 条件下很难检测到小偏差。大型异常者颞叶区域的 MR 信号变化大于中等异常者。对于右侧额盖皮层，观察到相反的模式。时间激活的强度与刺激开始后 110 毫秒左右的变化相关 ERP 的幅度相关，而额叶激活在 150 毫秒左右与变化相关的 ERP 相关。这些结果表明，右额鳃皮层是生成 MMN 的神经网络的一部分。讨论了这些发现的三种替代解释。 m 2002 年爱思唯尔科学。
The present study addresses the functional role of the temporal and frontal lobes in auditory change detection. Prior event-related potential (ERP) research suggested that the mismatch negativity (MMN) reflects the involvement of a temporofrontal network subserving auditory change detection processes and the initiation of an involuntary attention switch. In the present study participants were presented with repetitive spectrally rich sounds. Infrequent changes of either small (10% change), medium (30 10 change), or large (100% change) magnitude were embedded in the stimulus train. ERPs and fMRI measures were obtained in the same subjects in subsequent sessions. Significant hemodynamic activation in the superior temporal gyri (STG) bilaterally and the opercular part of the right inferior frontal gyrus was observed for large and medium deviants only. ERPs showed that small deviants elicited MMN when presented in silence but not when presented with recorded MR background noise, indicating that small deviants were hardly detected under fMRI conditions. The MR signal change in temporal lobe regions was larger for large than for medium deviants. For the right fronto-opercular cortex the opposite pattern was observed. The strength of the temporal activation correlated with the amplitude of the change-related ERP at around 110 ms from stimulus onset while the frontal activation correlated with the change-related ERP at around 150 ms. These results suggest that the right fronto-opercular cortex is part of the neural network generating the MMN. Three alternative explanations of these findings are discussed. m 2002 Elsevier Science.