Titanium alloy modified with anti-biofouling zwitterionic polymer to facilitate formation of bio-mineral layer.
Titanium alloy modified with anti-biofouling zwitterionic polymer to facilitate formation of bio-mineral layer.
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DOI：
10.1016/j.colsurfb.2017.01.018
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发表时间：
2017-04
期刊：
影响因子：
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通讯作者：
M. Nishida;T. Nakaji-Hirabayashi;H. Kitano;Yoshiyuki Saruwatari;K. Matsuoka
中科院分区：
文献类型：
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作者：
M. Nishida;T. Nakaji-Hirabayashi;H. Kitano;Yoshiyuki Saruwatari;K. Matsuoka
用聚（乙二醇）甲基丙烯酸酯磷酸酯（Phosmer PE）的自组装单层对钛（Ti）合金表面进行改性。两性离子单体（羧甲基甜菜碱，CMB）可以与表面结合的Phosmer PE共聚，由于钛合金表面和Phosmer PE的甲基丙烯酰基之间的柔性连接基。聚（CMB）（PCMB）改性的钛合金板表现出强烈的抑制蛋白质吸附和细胞粘附，并诱导约两倍的钙（Ca2+）沉积量相比，未改性的钛合金板。两性离子聚合物改性的表面不仅显示出增强的矿化簇的产生和生长，而且它们对生物衍生材料如蛋白质和细胞也高度不响应。因此，可以在钛合金表面上容易地形成高纯度和刚性的羟基磷灰石层，而不引入有机分子如蛋白质。本发明的表面改性技术和策略可应用于可植入矫形材料，作为促进与宿主组织（如大腿骨）整合的手段。
The surface of a titanium (Ti) alloy was modified with a self-assembled monolayer of poly(ethylene glycol) methacrylate phosphate (Phosmer PE). A zwitterionic monomer (carboxymethyl betaine, CMB) could be copolymerized with the surface-bound Phosmer PE due to a flexible linker between the Ti alloy surface and a methacryloyl group of Phosmer PE. The poly(CMB) (PCMB)-modified Ti alloy plate exhibited strong suppression of protein adsorption and cell adhesion, and induced approximately twice the amount of calcium (Ca2+) deposition as compared to the unmodified Ti alloy plate. The zwitterionic polymer-modified surfaces not only showed enhanced mineralization clusters creation and growth, but they were also highly non-responsive to biologically derived materials such as proteins and cells. Therefore, it is possible to easily form highly pure and rigid hydroxyapatite layers on Ti alloy surfaces without the incorporation of organic molecules such as proteins. The present surface modification technique and strategy can be applied to implantable orthopedic materials as a means of encouraging integration with host tissues, such as the thigh bone.