Psychophysical demonstration of bidirectional pain modulation (sensitization and desensitization) by ascending or descending progressions of thermal stimulus intensity
Psychophysical demonstration of bidirectional pain modulation (sensitization and desensitization) by ascending or descending progressions of thermal stimulus intensity
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DOI：
10.1016/j.brainres.2010.06.006
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发表时间：
2010-08-06
期刊：
影响因子：
2.9
通讯作者：
Mauderli, Andre P.
中科院分区：
文献类型：
--
作者：
Vierck, Charles J.;Riley, Joseph L., III;Mauderli, Andre P.
一种反应依赖性刺激的心理物理学方法呈现了一系列上升和下降的热刺激强度，这些热刺激强度保持了轻度疼痛（0-100量表上的20）或中度疼痛（35）的平均评级（设定点）。受试者提出了一系列交替的热刺激，增加，直到评级达到或超过设定点，然后降低，直到评级等于或小于设定点，然后增加，等等。图疼痛强度评级的上升和下降的刺激强度系列显着不同。在上升系列之后，下降系列期间的疼痛评级高于预测，而在下降系列之后，上升系列期间的疼痛评级低于预测。因此，神经系统检测并区分刺激强度的上升和下降趋势，并在增加或减少刺激强度的趋势方向上改变疼痛感觉的幅度。上升（致敏）趋势效应可能会增加病理性疼痛的程度，在没有治疗的情况下，下降（脱敏）趋势效应可能会提高降低疼痛敏感性的程序的疗效。(C)2010爱思唯尔有限公司版权所有。
A psychophysical method of response-dependent stimulation presented ascending and descending series of thermal stimulus intensities that maintained an average rating (setpoint) of mild pain (20 on a scale of 0-100) or moderate pain (35). Subjects were presented with alternating series of thermal stimuli that increased until ratings reached or exceeded the setpoint, then decreased until ratings equaled or were less than the setpoint, then increased, etc. Plots of pain intensity ratings differed substantially for series of ascending and descending stimulus intensities. After an ascending series, pain ratings during a descending series were higher than predicted, and after a descending series, pain ratings during an ascending series were lower than predicted. Thus, the nervous system detects and discriminates between ascending and descending trends in stimulus intensity and alters the magnitude of pain sensations in the direction of the trend of increasing or decreasing stimulus intensity. Ascending (sensitizing) trend effects may increase the magnitude of pathological pain in the absence of treatment, and descending (desensitizing) trend effects likely would enhance the efficacy of procedures that reduce pain sensitivity. (C) 2010 Elsevier B.V. All rights reserved.