Repetitive, selective angiography of individual vessels of the retina.
Repetitive, selective angiography of individual vessels of the retina.
复制标题
对视网膜单个血管进行重复、选择性血管造影。
DOI：
10.1097/00006982-198909020-00003
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Oncel,M
中科院分区：
文献类型：
--
作者：
Khoobehi,B;Niesman,MR;Peyman,GA;Oncel,M
结肠;最近的实验表明，使用激光或微波能量的可行性，外部控制释放的染料和药物从温度敏感的脂质体（脂质囊泡）。在本研究中，钙黄绿素，一种荧光染料，用于提高这种控制释放系统的体内能力。体外研究表明，与先前使用的荧光染料羧基荧光素相比，包封效率得到改善。使用改进的脂质体和染料系统在单次脂质体注射后长达2小时的时间内，在兔子和非人灵长类动物（猕猴）的视网膜分离部分中获得重复的“选择性血管造影”。实验结束一周后，灵长类动物视网膜的常规荧光素血管造影显示，即使在400多次单独的激光照射后，也没有可见的损伤。视网膜9：87-96，1989
colon; Recent experiments have shown the feasibility of using laser or microwave energy for the externally controlled release of both dyes and drugs from temperature-sensitive liposomes (lipid vesicles). In the present study, calcein, a fluorescent dye, was used to improve the in vivo capabilities of this controlled release system. In vitro studies showed that the encapsulation efficiency was improved when compared to carboxyfluorescein, the fluorescent dye used previously. The improved liposome and dye system was used to obtain repetitive," selective angiograms" in isolated segments of the retina in rabbits and in a nonhuman primate (Macaca mulatta) over a period of up to 2 hours after a single liposome injection. Conventional fluorescein angiography of the primate retina one week after the end of the experiments showed no visible damage, even after more than 400 individual laser exposures. RETINA 9: 87-96, 1989