MENSTRUAL IRREGULARITIES ARE MORE COMMON IN ADOLESCENTS WITH TYPE-1 DIABETES - ASSOCIATION WITH POOR GLYCEMIC CONTROL AND WEIGHT-GAIN
MENSTRUAL IRREGULARITIES ARE MORE COMMON IN ADOLESCENTS WITH TYPE-1 DIABETES - ASSOCIATION WITH POOR GLYCEMIC CONTROL AND WEIGHT-GAIN
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DOI：
10.1111/j.1464-5491.1994.tb00307.x
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发表时间：
1994-06-01
影响因子：
3.5
通讯作者：
DUNGER, DB
中科院分区：
文献类型：
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作者：
ADCOCK, CJ;PERRY, LA;DUNGER, DB
对绝经后1型糖尿病女孩的卵巢功能进行了评价。将24名1型糖尿病青少年的月经史与24名年龄和性别匹配的对照组进行比较。从1型糖尿病受试者中采集空腹血样，用于测量卵巢和肾上腺性激素、LH和FSH、葡萄糖和胰岛素、胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子结合蛋白-1（IGFBP-1）;并进行卵巢超声扫描。与对照组相比，1型糖尿病患者的月经不规律更为普遍（54% vs 21%，p < 0.01），其平均体重指数（BMI）更大（22.3 +/- 0.5（+/- SEM）vs 20.7 +/- 0.6 kg m-2，p < 0.05）。月经不规律的1型糖尿病受试者（与有规律周期的糖尿病受试者相比）的HbA 1（12.8 +/- 0.4 vs 10.5 +/-0.5%，p < 0.01）和BMI（23.2 +/- 0.6 vs 21.4 +/- 0.6 kg M-2，p < 0.05）与性激素结合球蛋白（SHBG）降低相关（37.2 +/- 4.0 vs 52.6 +/- 4.0 nmol l-1，p < 0.025）和IGF-I（1.4 +/- 0.2 vs 2.2 +/- 0.2穆尔-1，p < 0.025）以及更高的LH：FSH比值（2.6 +/- 0.5 vs 1.4 +/- 0.2，p < 0.05）。10/13例（77%）患者出现多囊卵巢改变，周期不规则。月经不规则在月经后1型糖尿病女孩中很常见，与血糖控制不良和体重增加有关。多囊卵巢改变的明显高发病率需要进一步研究。
Ovarian function in post-menarchal girls with Type 1 diabetes was evaluated. Menstrual histories from 24 adolescents with Type 1 diabetes were compared with those from 24 age and sex matched controls. A fasting blood sample was obtained from subjects with Type 1 diabetes for the measurement of ovarian and adrenal sex hormones, LH and FSH, glucose and insulin, insulin-like growth factor-I (IGF-I), and insulin-like growth factor binding protein-1 (IGFBP-1); and an ovarian ultrasound scan was performed. Menstrual irregularity was more prevalent in patients with Type 1 diabetes than controls (54 % vs 21 %, p < 0.01) and their mean body mass index (BMI) was greater (22.3 +/- 0.5 (+/- SEM) vs 20.7 +/- 0.6 kg m-2, p < 0.05). Subjects with Type 1 diabetes with irregular menses (when compared with diabetic subjects with a regular cycle) had a significantly higher HbA1 (12.8 +/- 0.4 vs 10.5 +/- 0.5 %, p < 0.01) and BMI (23.2 +/- 0.6 vs 21.4 +/- 0.6 kg M-2, p < 0.05) associated with a lower sex hormone binding globulin (SHBG) (37.2 +/- 4.0 vs 52.6 +/- 4.0 nmol l-1, p < 0.025) and IGF-I (1.4 +/- 0.2 vs 2.2 +/- 0.2 mUl-1, p < 0.025) and a higher LH:FSH ratio (2.6 +/- 0.5 vs 1.4 +/- 0.2, p < 0.05). Polycystic ovarian changes were identified in 10/13 (77 %) of these patients with an irregular cycle. Menstrual irregularity is common in post-menarchal girls with Type 1 diabetes and is associated with poor glycaemic control and weight gain. The apparent high incidence of polycystic ovarian change requires further investigation.