Screening guidelines for non-AIDS defining cancers in HIV-infected individuals.
Screening guidelines for non-AIDS defining cancers in HIV-infected individuals.
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DOI：
10.1097/cco.0b013e328363e04a
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发表时间：
2013-09
影响因子：
3.4
通讯作者：
Aboulafia DM
中科院分区：
文献类型：
--
作者：
Mani D;Aboulafia DM
艾滋病毒/艾滋病（PLWHA）感染者中非艾滋病定义的恶性肿瘤（non-ADM）的负担日益增加，突出了癌症预防和早期发现的必要性。在这篇文章中，我们提出了非ADM在PLWHA筛查指南。在国家肺筛查试验数据中，低剂量螺旋胸部计算机断层扫描（LDCT）筛查肺癌显示肺癌和全因死亡率降低。最近的研究表明，在PLWHA肝移植的良好经验。过度诊断在乳腺癌和前列腺癌筛查中很常见。与未感染艾滋病毒的个体相比，与男性发生性关系的艾滋病毒感染男性（MSM）、其他男性和女性的肛门癌发病率显著较高。对一般人群的筛查建议可适用于艾滋病毒感染者/艾滋病患者的乳腺癌、结肠癌和前列腺癌。在高危的PLWHA患者中，可以考虑用LDCT进行肺癌筛查。美国肝脏疾病研究协会建议，每两年进行一次超声检查，可应用于肝细胞癌的高危PLWHA。所有感染艾滋病毒的成年人都应该在专门的中心接受肛门癌筛查，作为临床护理的一部分。
The growing burden of non-AIDS-defining malignancies (non-ADM) among people living with HIV/AIDS (PLWHA) highlights the need for cancer prevention and early detection. In this article we propose screening guidelines for non-ADM in PLWHA. Screening for lung cancer with low-dose helical chest computerized tomography (LDCT) in the National Lung Screening Trial data demonstrated a decrease in lung cancer and all-cause mortality. Recent studies have demonstrated a favorable experience among PLWHA with liver transplantation. Over-diagnosis is common with breast and prostate cancer screening. Anal cancer rates were substantially higher for HIV-infected men who have sex with men (MSM), other men, and women compared with HIV-uninfected individuals. Screening recommendations for the general population can be applied to PLWHA patients for breast, colon and prostate cancer. Screening for lung cancer with LDCT could be considered in PLWHA at risk. American Association for the Study of Liver Diseases screening recommendations with biennial ultrasonography may be applied to at-risk PLWHA for hepatocellular carcinoma. All HIV-infected adults should be offered anal cancer screening as part of clinical care at specialized centers.