New insights into the mechanisms controlling the bronchial mucus balance
New insights into the mechanisms controlling the bronchial mucus balance
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DOI：
10.1371/journal.pone.0199319
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发表时间：
2018-06-22
期刊：
影响因子：
3.7
通讯作者：
Haut, Benoit
中科院分区：
文献类型：
--
作者：
Karamaoun, Cyril;Sobac, Benjamin;Haut, Benoit
在这项工作中，我们的目标是分析和比较的机制控制的粘液在支气管区域的肺的健康成人，在休息和在通常的大气条件下。该分析基于气道中粘液的平衡方程，该平衡方程由旨在表征呼吸期间支气管粘液中所含水分的蒸发的计算工具完成。一个理想化的代表性的肺部，基于韦伯的形态计量模型，使用。结果表明，控制气道中粘液体积的机制取决于气道在肺的支气管区域中的定位。在近端世代中，气道中粘液的体积主要由其所含水分的蒸发和上皮细胞或粘膜下腺体对粘液层的补充来控制。然而，在支气管区域的这一部分中，纤毛跳动对于运输粘液并因此消除其中捕获的灰尘和病原体仍然具有根本的重要性。另一方面，在支气管区域的远端世代中，气道中的粘液体积主要由粘液纤毛运输和上皮对液体的吸收控制。这种吸收是纤毛沿着世代进行粘液置换的结果，上皮和气道表面层之间的界面面积逐渐减小。所得数值结果与先前发表的实验数据吻合良好，从而验证了我们的方法。我们还简要讨论了我们的研究结果如何提高对肺部疾病的理解，并可能提高肺部疾病的治疗。
In this work, we aim to analyze and compare the mechanisms controlling the volume of mucus in the bronchial region of the lungs of a healthy human adult, at rest and in usual atmospheric conditions. This analysis is based on a balance equation for the mucus in an airway, completed by a computational tool aiming at characterizing the evaporation, during respiration, of the water contained in the bronchial mucus. An idealized representation of the lungs, based on Weibel's morphometric model, is used. The results indicate that the mechanisms controlling the volume of mucus in an airway depend on the localization of the airway in the bronchial region of the lungs. In the proximal generations, the volume of mucus in an airway is mainly controlled by the evaporation of the water it contains and the replenishment, with water, of the mucus layer by epithelial cells or the submucosal glands. Nevertheless, cilia beating in this part of the bronchial region remains of fundamental importance to transport the mucus and hence to eliminate dust and pathogens trapped in it. On the other hand, in the distal generations of the bronchial region, the volume of mucus in an airway is mainly controlled by the mucociliary transport and by the absorption of liquid by the epithelium. This absorption is a consequence of the mucus displacement by the cilia along generations with an interface between the epithelium and the airway surface layer of decreasing area. The numerical results obtained are in good agreement with previously published experimental data, thus validating our approach. We also briefly discuss how our results can improve the understanding and, possibly, the treatment of pulmonary diseases.