Feedforward somatosensory inhibition is normal in cervical dystonia.
Feedforward somatosensory inhibition is normal in cervical dystonia.
复制标题
前馈体感抑制在颈肌张力障碍中是正常的。
DOI：
10.1016/j.parkreldis.2014.12.026
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发表时间：
2015
影响因子：
4.1
通讯作者：
Ferrè ER
中科院分区：
文献类型：
--
作者：
Ferrè ER
背景皮层抑制不足是肌张力障碍的一个重要病理生理学发现。据报道，阈下感觉刺激可短暂抑制躯体感觉处理。在这里，我们调查是否这样的阈下前馈抑制减少颈肌张力障碍患者。MethodsSixteen颈部肌张力障碍患者和16个匹配的健康对照进行了体感检测任务。我们测量了下降的敏感性，以检测阈值水平的数字神经休克时，它是由一个阈下条件反射休克之前，相比，当它不是。ResultsSubliminal条件反射休克降低敏感性阈值刺激在患者和对照组相似的程度，提示在颈性肌张力障碍患者中，躯体感觉阈下前馈抑制是正常的。肌张力障碍患者。我们的研究结果限定了以前的概念，感觉运动抑制处理中的一般张力障碍缺陷。
BackgroundInsufficient cortical inhibition is a key pathophysiological finding in dystonia. Subliminal sensory stimuli were reported to transiently inhibit somatosensory processing. Here we investigated whether such subliminal feedforward inhibition is reduced in patients with cervical dystonia.MethodsSixteen cervical dystonia patients and 16 matched healthy controls performed a somatosensory detection task. We measured the drop in sensitivity to detect a threshold-level digital nerve shock when it was preceded by a subliminal conditioning shock, compared to when it was not.ResultsSubliminal conditioning shocks reduced sensitivity to threshold stimuli to a similar extent in both patients and controls, suggesting that somatosensory subliminal feedforward inhibition is normal in cervical dystonia.ConclusionSomatosensory feedforward inhibition was normal in this group of cervical dystonia patients. Our results qualify previous concepts of a general dystonic deficit in sensorimotor inhibitory processing.