ACTIVE PEPTIDES IN THE SKINS OF 100 AMPHIBIAN SPECIES FROM AUSTRALIA AND PAPUA-NEW-GUINEA
ACTIVE PEPTIDES IN THE SKINS OF 100 AMPHIBIAN SPECIES FROM AUSTRALIA AND PAPUA-NEW-GUINEA
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DOI：
10.1016/0742-8413(84)90137-3
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发表时间：
1984-01-01
影响因子：
3.9
通讯作者：
ENDEAN, R
中科院分区：
文献类型：
--
作者：
ERSPAMER, V;ERSPAMER, GF;ENDEAN, R
Extracts prepared from the dried skins of .apprx. 100 amphibian species from Australia and Papua New Guinea were subjected to biological screening in order to determine the nature and amounts of peptides active on smooth muscle preparations and systemic blood pressure present in these extracts. The most frequently and abundantly occurring peptides were those of the caerulein, bombesin and tachykinin peptide families represented, respectively, by caerulein: litorin, Glu(OMe)2-litorin and Glu(OEt)2-litorin; uperolein and Lys5-Thr6-physalaemin. Bradykinin-like peptides seem to have a rather diffuse distribution, in the species examined, but so far no peptide of this family was isolated and sequenced. The only angiotensin-like peptide ever found in amphibian skin, crinia angiotensin II, was isolated from skin extracts of a few species, belonging to the genera Crinia, Geocrinia, Ranidella and Litoria. The array of peptides occurring in amphibians from Australia and Papua New Guinea is destined to increase, because several apparently novel peptides have been identified in skin extracts by bioassay and radioimmunoassay.
