Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma.
Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma.
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DOI：
10.1111/j.1523-1755.2005.00216.x
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发表时间：
2005-04
影响因子：
19.6
通讯作者：
K. Tozawa;T. Okamoto;N. Kawai;Y. Hashimoto;Y. Hayashi;K. Kohri
中科院分区：
文献类型：
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作者：
K. Tozawa;T. Okamoto;N. Kawai;Y. Hashimoto;Y. Hayashi;K. Kohri
背景肿瘤细胞与内皮细胞之间的相互作用在肿瘤的侵袭和转移中起着重要作用。在众多的细胞粘附分子中，肿瘤细胞表面表达的唾液酸刘易斯抗原与内皮细胞表面表达的E-选择素之间的同源相互作用被认为是肿瘤细胞粘附于内皮的关键。方法采用免疫组织化学方法检测45例肾细胞癌组织中唾液酸刘易斯X（sL（X））的表达。结果：肾癌组织sL（X）免疫反应性不仅与常规病理参数相关，而且可作为判断肾癌预后的一个有用指标。结论西咪替丁对sL（X）高表达的肾癌的治疗作用可能与其抑制唾液酸刘易斯抗原配体分子E-选择素的表达有关，西咪替丁对sL（X）高表达的肾癌的复发和转移也有抑制作用。
BACKGROUND Interaction between tumor cells and endothelium plays a major role in cancer invasion and metastasis. Among various cell adhesion molecules, the cognate interaction between sialyl Lewis antigen expressed in the tumor cell surface and E-selectin expressed on endothelial cells is considered to be crucial for the tumor cell adhesion to the endothelium. METHODS The sialyl Lewis X (sL(X)) expression in 45 specimens from renal cell carcinoma patients was examined using immunohistochemistry. RESULTS In this study, we demonstrate that the immunoreactivity for sL(X) in renal cell carcinoma specimens not only correlates with conventional histopathologic parameters but also serves as a useful indicator for the prognosis of renal cell carcinoma. CONCLUSION Since beneficial effect of cimetidine has been reported and ascribed to its inhibitory action on the expression of E-selectin, a ligand molecule of sialyl Lewis antigen, cimetidine may also show inhibitory effect on the tumor recurrence and metastasis of renal cell carcinoma with high level of sL(X) expression.