Optimal dynamic treatment regimes
Optimal dynamic treatment regimes
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DOI：
10.1111/1467-9868.00389
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发表时间：
2003-01-01
影响因子：
5.8
通讯作者：
Murphy, SA
中科院分区：
文献类型：
--
作者：
Murphy, SA
动态治疗方案是一个决策规则列表，每个时间间隔一个，用于如何根据个人不断变化的状态调整治疗水平。本文的目标是使用实验或观测数据来估计导致最大平均响应的决策制度。为了阐明我们的目标和陈述假设，我们使用潜在结果模型。该方法仅对与估计最优规则目标直接相关的量进行光滑参数假设。我们通过一个小型模拟来说明所提出的方法。
A dynamic treatment regime is a list of decision rules, one per time interval, for how the level of treatment will be tailored through time to an individual's changing status. The goal of this paper is to use experimental or observational data to estimate decision regimes that result in a maximal mean response. To explicate our objective and to state the assumptions, we use the potential outcomes model. The method proposed makes smooth parametric assumptions only on quantities that are directly relevant to the goal of estimating the optimal rules. We illustrate the methodology proposed via a small simulation.