Advanced glycation end products (AGEs) and the soluble receptor for AGE (sRAGE) in patients with type 1 diabetes and coeliac disease
Advanced glycation end products (AGEs) and the soluble receptor for AGE (sRAGE) in patients with type 1 diabetes and coeliac disease
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DOI：
10.1016/j.numecd.2014.10.009
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发表时间：
2015-02-01
影响因子：
3.9
通讯作者：
Simsek, S.
中科院分区：
文献类型：
--
作者：
Bakker, S. F.;Tushuizen, M. E.;Simsek, S.
背景和目的：晚期糖基化终点（AGE）产品在糖尿病并发症的进展中起作用。无谷蛋白饮食（GFD）可能会影响因乳糜泻（CD）而坚持GFD的患者的AGE水平。本研究的目的是比较伴有（T1DM + CD）和不伴有CD （T1DM - CD）的1型糖尿病（T1DM）患者和健康对照者的皮肤AGE水平和可溶性受体AGE水平（sRAGE）。方法和结果：我们招募了25例T1DM + CD和25例T1DM e CD患者，年龄、性别、糖尿病病程和血糖控制与25例健康对照相匹配。我们收集了人口统计学、临床和生化特征，包括皮肤自身荧光（AF）、sRAGE和hs-CRP水平。T1DM患者的持续时间为30 +/- 14年（+CD）和29 +/- 14年（-CD），而T1DM +CD患者的CD持续时间为14 +/- 10年。T1DM患者皮肤AF水平高于健康对照组（2.5 +/- 0.6比1.9 +/- 0.4,p < 0.01），皮肤AF与年龄独立相关（r = 0.72, p < 0.01）。与健康对照相比，T1DM - CD患者的sRAGE水平更高（1554 +/- 449比1309 +/- 400，p = 0.049），且与肌酐水平独立相关（r = 0.32, p < 0.01）。结论：我们的研究表明，与健康对照组相比，T1DM患者的皮肤AGE和sRAGE水平升高。伴有或不伴有CD的T1DM患者的皮肤AF或sRAGE水平无差异。目前的研究表明，T1DM和T1DM + CD患者微血管并发症的差异不是由于皮肤AF或sRAGE水平的差异。(C) 2014 Elsevier B.V.版权所有
Background and aims: Advanced glycation end (AGE) products play a role in the progression of diabetic complications. Gluten-free diet (GFD) might affect AGE levels in patients who adhere to a GFD because of coeliac disease (CD). The aim of our study was to compare skin AGE levels and soluble receptor AGE levels (sRAGE) in patients with type 1 diabetes (T1DM) with (T1DM + CD) and without CD (T1DM - CD) and healthy controls.Methods and results: We recruited 25 T1DM + CD and 25 T1DM e CD patients, matched for age, gender, diabetes duration, and glycaemic control alongside 25 healthy controls. We collected demographic, clinical and biochemical characteristics, including skin autofluorescence (AF), sRAGE and hs-CRP levels. The duration of T1DM in patients was 30 +/- 14 (+CD) and 29 +/- 14 years (-CD), whereas CD duration in T1DM + CD patients was 14 +/- 10 years. Skin AF levels in T1DM patients were higher compared to healthy controls (2.5 +/- 0.6 versus 1.9 +/- 0.4, p < 0.01) and skin AF was independently associated with age (r = 0.72, p < 0.01). sRAGE levels were higher in T1DM - CD patients compared to healthy controls (1554 +/- 449 versus 1309 +/- 400, p = 0.049) and independently associated with creatinine levels (r = 0.32, p < 0.01).Conclusion: Our study demonstrates that skin AGE and sRAGE levels are elevated in T1DM patients compared with healthy controls. No difference in skin AF or sRAGE levels between T1DM patients with or without CD were observed. The present study suggests that differences in microvascular complications between T1DM and T1DM + CD patients are not due to differences in skin AF or sRAGE levels. (C) 2014 Elsevier B.V. All rights reserved.