Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target for Atherosclerosis.
Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target for Atherosclerosis.
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作者：
Li J;Taylor AM;Manichaikul A;Angle JF;Shi W
由氧化脂蛋白引发的血管炎症驱动动脉粥样硬化斑块的发生、发展甚至破裂。然而，到目前为止，没有生物标志物与氧化脂质诱导的血管炎症直接相关。网织红蛋白2（RCN 2）是动脉壁细胞中基础和氧化脂质诱导的细胞因子产生的关键调节因子。我们评估了循环RCN 2识别患有动脉粥样硬化或有发生动脉粥样硬化风险的受试者的潜力。免疫组化分析显示，丰富的RCN 2表达在正常动脉的内皮和外膜和动脉粥样硬化病变的人类和小鼠。动脉粥样硬化易感的C57 BL/6（B6）小鼠的血浆Rcn 2水平高于耐药的C3 H小鼠。高脂饲料喂养提高血浆Rcn 2水平的两个菌株。在人类中，与健康对照相比，患有冠状动脉疾病（CAD）或外周动脉疾病（PAD）的患者显示出升高的血清RCN 2水平。在92例CAD患者的队列中，血清RCN 2与HDL胆固醇和K+水平呈显著负相关，并与白色血细胞计数、Na+、他汀类药物治疗和舒张压呈相关趋势。HDL处理抑制内皮细胞中Rcn 2的表达。这项研究表明，循环中的RCN 2是一种潜在的非侵入性生物标志物，用于识别动脉粥样硬化患者，HDL通过下调内皮细胞中RCN 2的表达来预防动脉粥样硬化。
Vascular inflammation initiated by oxidized lipoproteins drives initiation, progression, and even rupture of atherosclerotic plaques. Yet, to date, no biomarker is directly linked to oxidized lipid-induced vascular inflammation. Reticulocalbin 2 (RCN2) is a key regulator of basal and oxidized lipid-induced cytokine production in arterial wall cells. We evaluated the potential of circulating RCN2 to identify subjects with or at risk of developing atherosclerosis. Immunohistochemical analysis revealed abundant RCN2 expression in the endothelium and adventitia of normal arteries and in atherosclerotic lesions of both humans and mice. Atherosclerosis-susceptible C57BL/6 (B6) mice had higher plasma Rcn2 levels than resistant C3H mice. High-fat diet feeding raised plasma Rcn2 levels of both strains. In humans, patients with coronary artery disease (CAD) or peripheral artery disease (PAD) showed elevated serum RCN2 levels compared to healthy controls. In a cohort of 92 CAD patients, serum RCN2 exhibited a significant inverse correlation with HDL cholesterol and K+ levels and a trend toward association with white blood cell account, Na+, statin treatment, and diastolic blood pressure. HDL treatment suppressed Rcn2 expression in endothelial cells. This study suggests that circulating RCN2 is a potential non-invasive biomarker for identifying individuals with atherosclerosis and HDL protects against atherosclerosis by downregulation of RCN2 expression in endothelial cells.
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影响因子：
6.5
作者：
Brown, MD;Jin, L;Shi, WB
通讯作者：
Shi, WB
DOI：
10.1161/01.atv.14.1.133
发表时间：
1994-01-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
NAKASHIMA, Y;PLUMP, AS;ROSS, R
通讯作者：
ROSS, R
影响因子：
24
作者：
Virmani, R;Burke, AP;Kolodgie, FD
通讯作者：
Kolodgie, FD
影响因子：
4.4
作者：
Nakamura E;Sato Y;Iwakiri T;Yamashita A;Moriguchi-Goto S;Maekawa K;Gi T;Asada Y
通讯作者：
Asada Y
动脉粥样硬化的炎症。
DOI：
10.1161/atvbaha.108.179705
发表时间：
2012-09
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Libby P
通讯作者：
Libby P