Ciprofloxacin penetration into the pulmonary parenchyma in Japanese patients
Ciprofloxacin penetration into the pulmonary parenchyma in Japanese patients
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DOI：
10.1007/s00595-006-3393-4
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发表时间：
2007-04-01
期刊：
影响因子：
2.5
通讯作者：
Shimizu, Kazuo
中科院分区：
文献类型：
--
作者：
Haraguchi, Shuji;Hioki, Masafumi;Shimizu, Kazuo
目的：评价环丙沙星静脉注射对日本肺癌患者肺实质的穿透程度。方法：对10例日本非小细胞肺癌患者静脉注射环丙沙星1h。切除肺时取正常肺实质1 g，血清1 ml进行分析。采用高效液相色谱法测定环丙沙星浓度。结果：环丙沙星给药结束至肺切除平均时间为135±55 min（范围75 ~ 223 min）。肺实质和血清中环丙沙星平均浓度分别为4.9 +/- 2.0 μ g/g（范围2.1-7.9）和1.5 +/- 0.7 μ g/ml（范围0.8-2.7）。平均组织/血清浓度比为3.6 +/- 2.2（范围1.9-8.7）。结论：日本患者静脉给药后肺实质中环丙沙星浓度在至少75 min至4 h内均高于最低抑菌浓度。
Purpose: To assess the degree of penetration of intravenous (i.v.) ciprofloxacin into the lung parenchyma resected for lung carcinoma in Japanese patients.Methods: Ciprofloxacin was given i.v. over 1h to ten Japanese patients with non-small cell lung carcinoma. We took 1 g of normal lung parenchyma and 1 ml of blood serum for analysis when the lung was resected. Ciprofloxacin concentrations were determined by high-performance liquid chromatography.Results: The mean time from the end of ciprofloxacin administration to lung resection was 135 +/- 55 min (range, 75-223 min). The mean concentrations of ciprofloxacin in the lung parenchyma and blood serum were 4.9 +/- 2.0 mu g/g (range, 2.1-7.9) and 1.5 +/- 0.7 mu g/ml (range, 0.8-2.7). The mean tissue per serum concentration ratio was 3.6 +/- 2.2 (range, 1.9-8.7).Conclusions: The concentrations of ciprofloxacin in the lung parenchyma after i.v. administration in Japanese patients were above the minimal inhibitory concentration for bacteria from at least 75 min until 4 h later.