Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI
Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI
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DOI：
10.1002/hbm.20081
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发表时间：
2005-03-01
影响因子：
4.8
通讯作者：
Hui, KKS
中科院分区：
文献类型：
--
作者：
Napadow, V;Makris, N;Hui, KKS
这项功能性磁共振成像（fMRI）研究的目的是比较不同频率电针与传统中医手工针灸的中枢效应。虽然不像手工针灸那样经过时间考验，但电针确实具有客观、可量化地设定刺激频率和强度的优点。在 ST-36 穴位进行手法针刺、2 Hz 和 100 Hz 电针以及触觉控制刺激。总体而言，电针（尤其是低频）比手动针灸产生了更广泛的功能磁共振成像信号增加，并且所有针灸刺激都比我们类似安慰剂的触觉控制刺激产生了更广泛的反应。针刺使前岛叶血流动力学信号增加，边缘和旁边缘结构减少，包括杏仁核、前海马、膝下和压后扣带皮层、腹内侧前额叶皮层、额叶和颞极，而触觉控制刺激则未见这种结果。只有电针在前中扣带皮层中产生显着的信号增加，而2Hz电针在脑桥中缝区域产生信号增加。所有形式的刺激（针灸和控制）都会产生 SII 信号增加。这些发现支持这样一种假设，即无论具体的针灸方式如何，边缘系统都是针灸效果的核心，尽管这些方式的潜在神经生物学机制确实存在一些差异，并且可能有助于优化它们在临床应用中的未来使用。 (C) 2004 Wiley-Liss, Inc.
The goal of this functional magnetic resonance imaging (fMRI) study was to compare the central effects of electroacupuncture at different frequencies with traditional Chinese manual acupuncture. Although not as time-tested as manual acupuncture, electroacupuncture does have the advantage of setting stimulation frequency and intensity objectively and quantifiably. Manual acupuncture, electroacupuncture at 2 Hz and 100 Hz, and tactile control stimulation were carried out at acupoint ST-36. Overall, electroacupuncture (particularly at low frequency) produced more widespread fMRI signal increase than manual acupuncture did, and all acupuncture stimulations produced more widespread responses than did our placebo-like tactile control stimulation. Acupuncture produced hemodynamic signal increase in the anterior insula, and decrease in limbic and paralimbic structures including the amygdala, anterior hippocampus, and the cortices of the subgenual and retrosplenial cingulate, ventromedial prefrontal cortex, frontal, and temporal poles, results not seen for tactile control stimulation. Only electroacupuncture produced significant signal increase in the anterior middle cingulate cortex, whereas 2-Hz electroacupuncture produced signal increase in the pontine raphe area. All forms of stimulation (acupuncture and control) produced signal increase in SII. These findings support a hypothesis that the limbic system is central to acupuncture effect regardless of specific acupuncture modality, although some differences do exist in the underlying neurobiologic mechanisms for these modalities, and may aid in optimizing their future usage in clinical applications. (C) 2004 Wiley-Liss, Inc.