Effects of filtering methods on muscle and fat cross-sectional area measurement by pQCT: a technical note
Effects of filtering methods on muscle and fat cross-sectional area measurement by pQCT: a technical note
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DOI：
10.1088/0967-3334/32/12/n01
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发表时间：
2011-12-01
影响因子：
3.2
通讯作者：
Bemben, Debra A.
中科院分区：
文献类型：
--
作者：
Sherk, Vanessa D.;Bemben, Michael G.;Bemben, Debra A.
外周定量计算机断层扫描 (pQCT) 最常用于四肢的骨密度和形态评估，但它也可以通过分割代表不同组织的区域来用于软组织面积量化。由于检测到的 X 射线光子较少而产生的统计噪声增加，因此扫描和分析较大大腿的横截面区域提出了特殊的挑战。本技术说明的目的是将使用无滤波器、弱平滑滤波器和强平滑滤波器的 Stratec 3000 pQCT 扫描对大腿中部的总肌肉和脂肪横截面积 (CSA) 测量值与公共领域图像处理程序 Image J 分析的大腿中部 MRI 扫描的 CSA 测量值进行比较。九名健康的男性和女性参与了这项研究。 MRI 和强过滤 pQCT 图像之间的 CSA 没有显着差异，百分比差异范围从肌肉的 -3.1% 到脂肪的 +6.5%。 MRI 和带弱滤波器 (-24.0 +/- 38.0%) 或无滤波器 (-44.9 +/- 22.7%) 的 pQCT 之间肌肉 CSA 值的百分比差异与大腿总 CSA 密切相关 (r = 0.78-0.92, p < 0.05)。我们建议，如果使用强平滑滤波器，可以使用 pQCT 评估大腿中部的软组织面积测量。
Peripheral quantitative computed tomography (pQCT) is most commonly used for bone density and morphology assessment of the limbs, but it can also be used for soft tissue area quantification by segmenting regions representing different tissues. Scanning and analyzing cross-sectional areas of larger thighs present a special challenge due to increased statistical noise created from fewer detected x-ray photons. The purpose of this technical note is to compare total, muscle and fat cross-sectional area (CSA) measurements of the midthigh with Stratec 3000 pQCT scans using no filter, a weak smoothing filter and a strong smoothing filter to CSA measurements of midthigh MRI scans analyzed by Image J, a public domain image processing program. Nine healthy men and women participated in this study. CSAs did not differ significantly between MRI and strongly filtered pQCT images with per cent differences ranging from -3.1% for muscle to +6.5% for fat. The per cent difference in muscle CSA values between MRI and pQCT with the weak filter (-24.0 +/- 38.0%) or no filter (-44.9 +/- 22.7%) was strongly related to total thigh CSA (r = 0.78-0.92, p < 0.05). We propose that the midthigh can be assessed for soft tissue area measurements with pQCT, provided that strong smoothing filter is utilized.