White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive Decline
White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive Decline
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DOI：
10.1161/strokeaha.115.009475
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发表时间：
2015-09-01
期刊：
影响因子：
8.3
通讯作者：
van der Flier, Wiesje M.
中科院分区：
文献类型：
--
作者：
Benedictus, Marije R.;van Harten, Argonde C.;van der Flier, Wiesje M.
背景和目的：在主观认知能力下降的患者中，我们评估了小血管疾病是否与临床进展和认知能力下降相关。方法：我们纳入了334例主观认知能力下降的患者。随访3+/-2年。结果：53例（16%）患者临床进展为轻度认知障碍或痴呆。白质高强度与临床进展以及记忆力、注意力、执行功能和整体认知能力的逐年下降有关。微出血和腔隙与临床进展或认知能力下降无关。结论：在主观认知能力下降的患者中，白质高信号的患者临床进展和认知能力下降的风险增加。
Background and Purpose-In patients with subjective cognitive decline, we assessed whether small vessel disease was associated with clinical progression and cognitive decline.Methods-We included 334 patients with subjective cognitive decline. Follow-up was 3+/-2 years.Results-Fifty-three (16%) patients progressed clinically to mild cognitive impairment or dementia. White matter hyperintensities were associated with clinical progression and with annual decline on memory, attention, executive functioning, and global cognition. Microbleeds and lacunes were not associated with clinical progression or cognitive decline.Conclusions-In patients with subjective cognitive decline, patients with white matter hyperintensities are at increased risk of clinical progression and cognitive decline.