The GLU that holds cancer together: targeting GLUtamine transporters in breast cancer.
The GLU that holds cancer together: targeting GLUtamine transporters in breast cancer.
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DOI：
10.1016/j.ccell.2015.02.010
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发表时间：
2015-03
期刊：
影响因子：
50.3
通讯作者：
M. Moses;L. Neckers
中科院分区：
文献类型：
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作者：
M. Moses;L. Neckers
许多癌细胞需要外源谷氨酰胺来增殖、提供 TCA 循环中间体、脂质合成、mTOR 活性和活性氧的中和。在本期《癌细胞》中，Jeon 及其同事将化疗引起的内质网应激确定为针对谷氨酰胺依赖性的一种新策略。
Many cancer cells require exogenous glutamine for proliferation, supply of TCA cycle intermediates, lipid synthesis, mTOR activity, and neutralization of reactive oxygen species. In this issue ofCancer Cell, Jeon and colleagues identify chemotherapy-induced endoplasmic reticulum stress as a novel strategy to target glutamine dependence.