Polymer microring resonators for biochemical sensing applications
Polymer microring resonators for biochemical sensing applications
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DOI：
10.1109/jstqe.2005.862945
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发表时间：
2006-01-01
影响因子：
4.9
通讯作者：
Guo, LJ
中科院分区：
文献类型：
--
作者：
Chao, CY;Fung, W;Guo, LJ
聚合物微球谐振器被证明用于在不使用荧光标记的情况下感测生物分子。的microwave设备，制造的直接压印技术，具有类似于20000的高Q值。该特征为生化传感应用提供了高灵敏度和低检测限。利用这些特性，这些设备被用于检测和量化存在于围绕微波导的均匀溶液中的生物分子（均匀感测）或特异性地结合在波导表面上的生物分子（表面感测）。在前一种传感机制中，目前的设备可以检测到10（-7）折射率单位（RIU）的有效折射率变化;在后一种机制中，它们可以达到类似于250 pg/mm（2）的生物分子覆盖在微粒表面上的检测极限。此外，实验表明，该设备可以检测小和大的生物分子。
Polymer microring resonators were demonstrated for sensing biomolecules without using fluorescent labels. The microring devices, fabricated by a direct imprinting technique, possess high Q factors of similar to 20000. This feature provides high sensitivity and a low detection limit for biochemical sensing applications. With these properties, the devices were used to detect and quantify the biomolecules present either in a homogeneous solution that surrounds the microring waveguide (homogeneous sensing) or specifically bound on the waveguide surface (surface sensing). In the former sensing mechanism, the current devices can detect an effective index change of 10(-7) refractive index units (RIU); in the latter, they can reach a detection limit of similar to 250 pg/mm(2) of biomolecular coverage on the microring surface. In addition, the experiments show that the devices can detect both small and large biomolecules.