Self-destruction Dynamics of HIV-1 Quasi-species Population in the Presence of Mutagenic Activities
Self-destruction Dynamics of HIV-1 Quasi-species Population in the Presence of Mutagenic Activities
复制标题
HIV-1准种群体在诱变活动存在下的自我毁灭动态
DOI：
10.1016/j.procs.2013.09.213
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kouji Harada
中科院分区：
文献类型：
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作者：
Sakumura Y;Inagaki N;原田耕治;原田耕治;Kouji Harada
本研究的目的是建立一个替代艾滋病治疗cART的基础上使用多种抗艾滋病毒药物的基础理论。众所周知，HIV-1是经常突变的。艾滋病的替代疗法是通过诱导HIV-1 RNA（+）基因组的过量突变来驱使HIV-1准种群体自我毁灭的方法。也就是说，这种疗法利用HIV-1的易错性作为一种卑鄙的方式。本研究提出一个新的HIV-1数学模型，考虑病毒的动力学过程，如感染，复制，突变，和诱变活动，以控制HIV-1的突变率。该模型还考虑了四种HIV-1表型：复制速度快和慢，感染能力有活力和缺陷。数值模拟结果表明，随着HIV-1变异率的增加，准种种群将发生错误突变。此外，自我毁灭状态的局部渐近稳定性的分析表明，艾滋病的替代治疗在某些特定的病毒条件下是有效的。
The present study aims to establish fundamental theories for an alternative AIDS treatment for cART based on the use of multiple anti-HIV drugs. It is well known that HIV-1 is frequently-mutated. The alternative AIDS treatment is an approach to drive HIV-1 quasi-species population to self-destruction by inducing excess mutations to HIV-1 RNA(+) genome. Namely this therapy uses the HIV-1's error-prone character as an underhanded way. This study proposes a novel HIV-1 mathematical model considered viral kinetic processes such as infection, replication, mutation, and mutagenic activities to control HIV-1 mutation rate. The model also considers four HIV-1 phenotypes: fast and slow in replication rate and viable and defective in infectious ability. Numerical simulations of the model show that enhancement of HIV-1 mutation rate causes an error catastrophe to HIV-1 quasi-species population. Furthermore, analyses of local asymptotic stability of the self-destruction state reveal that the alternative AIDS treatment has effectiveness in certain specific viral conditions.