Obstetric outcomes of pregnancy after conservative treatment of endometrial cancer: Case series and literature review
Obstetric outcomes of pregnancy after conservative treatment of endometrial cancer: Case series and literature review
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DOI：
10.1016/j.tjog.2009.10.006
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发表时间：
2011-03-01
影响因子：
2.1
通讯作者：
Wang, Hsin-Shih
中科院分区：
文献类型：
--
作者：
Chao, An-Shine;Chao, Angel;Wang, Hsin-Shih
目的：评价子宫内膜癌保守治疗后怀孕的患者的妊娠过程和产科结局。材料和方法：病例系列和子宫内膜癌保留生育力治疗后妊娠妇女的系统审查。早期子宫内膜癌患者是通过1990年至2005年长庚纪念医院肿瘤登记和MEDLINE检索确定的。确诊病例采用保留生育力疗法。妊娠后辅助生殖技术和自然或排卵宫腔内人工授精被指定为第1组和第2组，分别为。结果：五个活产在三个患者的两套双胎妊娠交付。在MEDLINE检索文献中增加47名女性，有65例分娩，77例活产。第1组和第2组分别有15次和50次分娩。第1组有23例活产，包括4组双胞胎和2组三胞胎，而第2组有54例活产，包括2组双胞胎和1组三胞胎（p = 0.003）。在第1组中观察到7例早产，在第2组中观察到3例早产（p = 0.001）。第1组和第2组的剖宫产率分别为93.3%和22.0%（p < 0.001）。妊娠高血压和妊娠期糖尿病在两组之间有显著性差异（p = 0.035）。一位母亲在分娩后死于疾病。没有新生儿发病率reported.Conclusions：对于妇女谁已经完成了保守治疗早期子宫内膜癌，辅助生殖技术提供了一个选择的计划生育或慢性不排卵的那些。版权所有（C）2011，中华民国妇产科医学会.出版社：Elsevier Taiwan LLC All rights reserved.
Objective: To evaluate the pregnancy courses and obstetric outcomes in patients conceived after conservative treatment of endometrial cancer.Materials and Methods: Case series and systemic review of pregnancy women after fertility-sparing treatment of endometrial cancer. Patients with early stage endometrial cancer were identified through Tumor Registry in Chang Gung Memorial Hospital between 1990 and 2005 and MEDLINE search. Diagnosed cases were managed by fertility-sparing therapies. Pregnancies followed by assisted reproductive technology and spontaneous or ovulation with intrauterine insemination were designated as Group 1 and Group 2, respectively.Results: Five livebirths in three patients with two sets of twin pregnancy were delivered. Adding 47 women in the MEDLINE search literature, there were 65 deliveries with 77 livebirths. Groups 1 and 2 had 15 and 50 deliveries, respectively. Group 1 had 23 livebirths including four sets of twins and two sets of triplets, whereas 54 livebirths consisted of two sets of twins and one set of triplets were noted in Group 2 (p = 0.003). Seven preterm deliveries were noted in Group 1 and three in Group 2 (p = 0.001). Cesarean rate was 93.3% versus 22.0% (p < 0.001) in Groups 1 and 2, respectively. Pregnancy-induced hypertension and gestational diabetes mellitus were significant between the two groups (p = 0.035). One mother died of disease after delivery. No neonatal morbidity was reported.Conclusions: For women who had completed conservative treatments in early endometrial cancer, assisted reproductive technology provided a choice of scheduled conception for those with subfertility or chronic anovulation. Copyright (C) 2011, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. All rights reserved.