SIMULATION OF EARLY RADIATION-INDUCED DNA DAMAGE ON DIFFERENT TYPES OF CELL NUCLEI.
SIMULATION OF EARLY RADIATION-INDUCED DNA DAMAGE ON DIFFERENT TYPES OF CELL NUCLEI.
复制标题
不同类型细胞核的早期辐射诱导 DNA 损伤的模拟。
DOI：
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发表时间：
2018
影响因子：
1
通讯作者：
C. Villagrasa
中科院分区：
文献类型：
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作者：
Nicolas Tang;M. Bueno;S. Meylan;S. Incerti;I. Clairand;C. Villagrasa
这项工作提出了一个比较模拟早期辐射诱导的DNA损伤的双链断裂（DSB）的产量在三个不同的人体细胞核几何形状代表成纤维细胞，淋巴细胞和内皮细胞的质子和α粒子的不同能量和不同的照射配置。每个细胞核模型包括从分子水平到细胞周期G 0/G1期全人类基因组表示（6 Gbp）的DNA靶标的多尺度描述，并使用DnaFabric软件生成。这三个细胞核在形状、体积和DNA密度上不同。基于Geant 4-DNA的计算链考虑了物理、物理化学和化学阶段，用于模拟不同细胞核的辐照。结果表明，DSB/primary/μm随DNA密度的增加而增加，DSB/戈伊/Gbp随细胞核体积的增加而增加，表明细胞核的形状和大小对早期DNA损伤有影响，并可能在后期效应中起作用。
This work presents a comparison of simulated early radiation-induced DNA damage represented by yields of double-strand breaks (DSB) in three different human cell nuclei geometries representing fibroblasts, lymphocytes and endothelial cells for protons and alpha particles of different energies and for different irradiation configurations. Each cell nucleus model includes a multi-scale description of the DNA target from the molecular level to the whole human genome representation (6 Gbp) in the G0/G1 phase of the cell cycle and was generated with the DnaFabric software. The three nuclei differ in shape, volume, and therefore DNA density. A calculation chain based on Geant4-DNA that takes into account the physical, physico-chemical and chemical stages was used to simulate the irradiation of the different cell nuclei. Results show an increase of DSB/primary/μm with an increase of DNA density and an increase of DSB/Gy/Gbp with an increase of the cell nucleus volume which indicates that the cell nucleus shape and size have an impact on early DNA damage, which may play a role in latter effects.