Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.
Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.
复制标题
用III型肺炎球菌多糖免疫的小鼠的B细胞激活抗原特异性抑制T细胞。
DOI：
10.1084/jem.158.3.703
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发表时间：
1983-09-01
影响因子：
15.3
通讯作者：
Baker, P J
中科院分区：
文献类型：
--
作者：
Taylor, C E;Stashak, P W;Caldes, G;Prescott, B;Chused, T E;Brooks, A;Baker, P J
The transfer of B lymphocytes from mice immunized with type III pneumococcal polysaccharide (SSS-III) results in antigen-specific suppression of the antibody response of recipients immunized with SSS- III. Such suppression shares many features associated with low-dose paralysis, a phenomenon mediated by suppressor T cells; it reaches maximal levels 3 d after the transfer of viable or irradiated immune B cells and can be eliminated by the depletion of SSS-III-binding cells from spleen cell suspensions before transfer. In a two-step cell transfer experiment, purified T lymphocytes, isolated from recipients previously given immune B cells, caused suppression upon transfer to other mice immunized with SSS-III. Also, B-cell-induced suppression could be abrogated in a competitive manner by the infusion of amplifier T lymphocytes, as was previously demonstrated in the case of low-dose paralysis. These findings suggest that B cell surface components, presumably the idiotypic determinants of cell-associated antibody specific for SSS-III, are instrumental in activating suppressor T cells involved in regulating the magnitude of the antibody response to SSS- III.
