An olfactory sensory map in the fly brain
An olfactory sensory map in the fly brain
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DOI：
10.1016/s0092-8674(00)00021-0
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发表时间：
2000-07-21
期刊：
影响因子：
64.5
通讯作者：
Axel, R
中科院分区：
文献类型：
--
作者：
Vosshall, LB;Wong, AM;Axel, R
我们已经分离出果蝇中编码气味受体的“完整”基因库，并利用这些基因提供外周嗅觉系统组织的分子描述。果蝇气味受体的全部功能由 57 个基因编码。单个感觉神经元可能仅表达单个受体基因。表达给定基因的神经元将轴突投射到触角长袍中的一两个空间不变的肾小球。因此，昆虫大脑保留了受体激活的二维图，因此气味的质量可以通过触角叶中不同的活动空间模式进行编码。
We have isolated the "complete" repertoire of genes encoding the odorant receptors in Drosophila and employ these genes to provide a molecular description of the organization of the peripheral olfactory system. The repertoire of Drosophila odorant receptors is encoded by 57 genes. Individual sensory neurons are likely to express only a single receptor gene. Neurons expressing a given gene project axons to one or two spatially invariant glomeruli in the antennal robe. The insect brain therefore retains a two-dimensional map of receptor activation such that the quality of an odor may be encoded by different spatial patterns of activity in the antennal lobe.