The impact of maternal depression in pregnancy on early child development
The impact of maternal depression in pregnancy on early child development
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DOI：
10.1111/j.1471-0528.2008.01752.x
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发表时间：
2008-07-01
影响因子：
5.8
通讯作者：
Emond, A.
中科院分区：
文献类型：
--
作者：
Deave, T.;Heron, J.;Emond, A.
目的探讨母亲产后抑郁症与子女发育问题的关系。许多产后抑郁的妇女在怀孕期间也会抑郁。本研究的目的是检查母亲在怀孕期间的抑郁症状与18个月大的儿童发育之间的关系。设计一项前瞻性队列研究，埃文父母和儿童的纵向研究。设置前埃文县，英格兰西南部。人口所有在1991年4月至1992年12月期间分娩的孕妇，9244名妇女及其子女。方法通过邮寄问卷收集产前、妊娠18周和32周、出生后8周和8个月的数据，包括抑郁的自我报告测量（爱丁堡产后抑郁量表[EPDS]）。到他们的孩子18个月大的时候，妇女完成了五个进一步的问卷调查，他们的孩子的健康和development.Main结果措施，在18个月的儿童发展，使用修改后的丹佛发展筛查测试（修改DDST）。结果应用标准的12/13截止，1565（14%）妇女产前抑郁，但不是在任何时间点产后。采用改良的DDST，893（9%）的儿童在18个月大时发育迟缓。持续性抑郁（两个时间点EPDS >= 10）与发育迟缓相关（校正OR 1.34，95%CI 1.11-1.62）。应用12/13和14/15截止值得到了类似的结果。产后抑郁症进一步调整后，影响大小略有衰减。结论这些研究结果突出了抑郁症在怀孕期间的重要性。产后抑郁症对儿童发育的一些影响部分是由怀孕期间的抑郁症状引起的。
Objective Postpartum depression in mothers is associated with developmental problems in their children. Many women who are depressed following childbirth are also depressed during pregnancy. The aim of this study was to examine the associations between maternal depressive symptoms during pregnancy and child development at 18 months of age.Design A prospective cohort study, Avon Longitudinal Study of Parents and Children.Setting The former county of Avon, southwest England.Population All pregnant women in the defined area with delivery dates between April 1991 and December 1992, 9244 women and their children.Methods Data were collected antenatally, at 18 and 32 weeks of gestation and at 8 weeks and 8 months postnatally, through postal questionnaires, including a self-report measure of depression (Edinburgh Postnatal Depression Scale [EPDS]). By the time their child was 18 months old, women completed five further questionnaires about their children's health and development.Main outcome measure Child development at 18 months using a modified Denver Developmental Screening Test (modified DDST).Results Applying the standard 12/13 cutoff, 1565 (14%) women were depressed antenatally but not at either time-points postnatally. Employing the modified DDST, 893 (9%) children were developmentally delayed at 18 months of age. Persistent depression (EPDS >= 10 at both time-points) is associated with developmental delay (adjusted OR 1.34, 95% CI 1.11-1.62). Applying the 12/13 and 14/15 cutoffs gave similar results. After further adjustment for postnatal depression, the effect sizes were slightly attenuated.Conclusions These findings highlight the importance of depression in pregnancy. Some effects on child development attributed to postpartum depression are caused in part by depressive symptoms during pregnancy.