A general method for making bicyclic compounds with nitrogen at a bridgehead - application to the halichlorine spiro subunit
A general method for making bicyclic compounds with nitrogen at a bridgehead - application to the halichlorine spiro subunit
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DOI：
10.1039/b413481h
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发表时间：
2005-01-01
影响因子：
4.9
通讯作者：
Li, ZY
中科院分区：
文献类型：
--
作者：
Clive, DLJ;Yu, ML;Li, ZY
具有氮环的n保护氨基醛很容易转化为森田-贝利斯-希尔曼加合物；o -乙酰化和n -去保护导致在桥头堡有氮的双环结构的自发环化。
N-Protected beta-amino aldehydes having the nitrogen in a ring are easily converted into Morita-Baylis-Hillman adducts; O-acetylation and N-deprotection result in spontaneous cyclization to bicyclic structures having nitrogen at a bridgehead.