Prediction of neutrophil reduction using plasma paclitaxel concentration after administration in patients with uterine, ovarian, or cervical cancers in an outpatient clinic
Prediction of neutrophil reduction using plasma paclitaxel concentration after administration in patients with uterine, ovarian, or cervical cancers in an outpatient clinic
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DOI：
10.1007/s00280-017-3506-3
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发表时间：
2018-02-01
影响因子：
3
通讯作者：
Kagawa, Yoshiyuki
中科院分区：
文献类型：
--
作者：
Ishikawa, Motoaki;Kawai, Michiyasu;Kagawa, Yoshiyuki
紫杉醇（PTX）给药后24小时或更晚的血浆浓度可预测骨髓抑制。在这里，我们探讨了在门诊静脉注射PTX引起的中性粒细胞减少的预测标志物。30名患有子宫癌、卵巢癌或宫颈癌的妇女参加了这项研究。静脉输注PTX（平均剂量：167 mg/m2），随后使用卡铂。PTX给药后4 h采集血浆样品。对CYP 3A 5 *3、ABCB 1 1236 C > T、2677 G > T/A和3435 C > T进行基因分型。基因型与中性粒细胞计数减少无显著相关性。中性粒细胞减少率与患者的身高、给药当天的中性粒细胞计数和血浆PTX浓度相关。多元回归分析，这三个指标解释47.7%的中性粒细胞减少率的个体间变异。模型与血浆PTX浓度，患者的身高，和血浆6-α-羟基-紫杉醇/PTX浓度比也解释了30.0%的个体间变异性的中性粒细胞最低点计数后PTX administration.These结果表明，中性粒细胞减少后PTX管理可以部分预测的多元回归分析，包括在门诊收集的血浆浓度数据。
Plasma paclitaxel (PTX) concentration 24 h or later after PTX administration may predict myelosuppression. Here, we explored predictive markers for neutropenia induced by intravenous administration of PTX in an outpatient clinic.Thirty women suffering from uterine, ovarian or cervical cancer were enrolled in this study. PTX (mean dose: 167 mg/m(2)) was intravenously infused and followed by carboplatin. Plasma samples were obtained 4 h after PTX administration. Genotyping was carried out for CYP3A5*3, ABCB1 1236 C > T, 2677 G > T/A, and 3435 C > T.There was no significant relationship between genotype and reduced neutrophil count. Neutrophil reduction rate correlated with the patient's height, neutrophil count on the day of administration, and plasma PTX concentration. Multiple regression analysis with those three indices explained 47.7% of the interindividual variability of the neutrophil reduction rate. The model with plasma PTX concentration, patient's height, and plasma 6-alpha-hydroxy-paclitaxel /PTX concentration ratio also explained 30.0% of the interindividual variability for the neutrophil nadir count after PTX administration.These results indicate that neutrophil reduction after PTX administration can be partially predicted by multiple regression analysis involving plasma concentration data collected at outpatient clinics.