Differential recruitment of distinct amygdalar nuclei across appetitive associative learning
Differential recruitment of distinct amygdalar nuclei across appetitive associative learning
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DOI：
10.1101/lm.031070.113
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发表时间：
2013-06-01
影响因子：
2
通讯作者：
Petrovich, Gorica D.
中科院分区：
文献类型：
--
作者：
Cole, Sindy;Powell, Daniel J.;Petrovich, Gorica D.
杏仁核对奖励相关学习很重要，但在食欲学习过程中，这种异质结构中不同的细胞群是如何被招募的尚不清楚。在这里，我们使用Fos诱导来绘制在巴甫洛夫食欲条件反射的早期和后期训练过程中招募的杏仁核功能电路。我们发现，在训练的早期和后期阶段，音调-食物配对对不同的杏仁核进行了不同的招募，这表明了学习诱导可塑性的证据。值得注意的是，这些选择性激活的核属于可分离的子系统，在音调食物学习过程中，这些子系统的位置很好，可以同时通知皮层（认知）处理和行为控制。
The amygdala is important for reward-associated learning, but how distinct cell groups within this heterogeneous structure are recruited during appetitive learning is unclear. Here we used Fos induction to map the functional amygdalar circuitry recruited during early and late training sessions of Pavlovian appetitive conditioning. We found that a number of distinct amygdalar nuclei were differentially recruited by tone-food pairings during the early and late stages of training, suggesting evidence of learning-induced plasticity. Notably, these selectively activated nuclei belong to dissociable subsystems that are well placed to simultaneously inform cortical (cognitive) processing and behavioral control during tone-food learning.