Effects of the mold temperature on the mechanical properties and crystallinity of hydroxyapatite whisker-reinforced polyetheretherketone scaffolds
Effects of the mold temperature on the mechanical properties and crystallinity of hydroxyapatite whisker-reinforced polyetheretherketone scaffolds
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DOI：
10.1002/jbm.b.32859
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发表时间：
2013-05-01
影响因子：
3.4
通讯作者：
Roeder, Ryan K.
中科院分区：
文献类型：
--
作者：
Conrad, Timothy L.;Jaekel, David J.;Roeder, Ryan K.
多孔生物活性聚醚醚酮 (PEEK) 支架有可能取代金属支架，用于对小梁骨附近的永久植入物进行生物固定，例如椎间脊柱融合装置。本研究的目的是研究模具温度和 PEEK 粉末对采用压缩成型和致孔剂浸出制备的羟基磷灰石 (HA) 晶须增强 PEEK 支架的机械性能和结晶度的影响。在 340390 摄氏度的模具温度下使用 50 或 10 m PEEK 粉末、75 vol% 孔隙率和 20 vol% HA 晶须制备支架。在无侧限、单轴压缩下评估支架机械性能，并使用镜面反射傅立叶变换红外光谱测量 PEEK 基质结晶度。模具温度升高导致压缩模量、屈服强度和屈服应变增加，在大约 370 摄氏度时达到稳定水平。观察到 HA 增强材料在 PEEK 颗粒之间分离，这抑制了在低于 365 摄氏度的压缩成型过程中 PEEK 颗粒聚结，但也确保了生物活性 HA 增强材料暴露在支架支柱表面。模具温度升高还导致 PEEK 结晶度降低，特别是对于在高于 375 摄氏度下成型的支架。PEEK 粉末尺寸对支架机械性能和 PEEK 结晶度的影响相对较小。因此，本研究结果表明，HA增强PEEK支架应在370375℃下模压成型。在370375℃下成型的支架的表观压缩模量、屈服强度和屈服应变分别为7592 MPa、2.02.2 MPa和2.53.6%，在人体椎骨小梁表现出的范围内。 (c) 2013 年 Wiley periodicals, Inc. J Biomed Mater Res B 部分：Appl Biomater，2013 年。
Porous and bioactive polyetheretherketone (PEEK) scaffolds have potential to replace metallic scaffolds for biologic fixation of permanent implants adjacent to trabecular bone, such as interbody spinal fusion devices. The objective of this study was to investigate the effects of the mold temperature and PEEK powder on the mechanical properties and crystallinity of hydroxyapatite (HA) whisker-reinforced PEEK scaffolds prepared using compression molding and porogen leaching. Scaffolds were prepared at mold temperatures ranging 340390 degrees C with a 50 or 10 m PEEK powder, 75 vol% porosity, and 20 vol% HA whiskers. Scaffold mechanical properties were evaluated in unconfined, uniaxial compression and the PEEK matrix crystallinity was measured using specular reflectance Fourier transform infrared spectroscopy. Increased mold temperature resulted in increased compressive modulus, yield strength, and yield strain, reaching a plateau at approximate to 370 degrees C. HA reinforcements were observed to be segregated between PEEK particles, which inhibited PEEK particle coalescence during compression molding at temperatures less than 365 degrees C but also ensured that bioactive HA reinforcements were exposed on scaffold strut surfaces. Increased mold temperature also resulted in decreased PEEK crystallinity, particularly for scaffolds molded at greater than 375 degrees C. The PEEK powder size exhibited relatively minor effects on the scaffold mechanical properties and PEEK crystallinity. Therefore, the results of this study suggested that HA-reinforced PEEK scaffolds should be compression molded at 370375 degrees C. The apparent compressive modulus, yield strength, and yield strain for scaffolds molded at 370375 degrees C was 7592 MPa, 2.02.2 MPa, and 2.53.6%, respectively, which was within the range exhibited by human vertebral trabecular bone. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.