Prostanoids and Hair Follicles: Implications for Therapy of Hair Disorders.
Prostanoids and Hair Follicles: Implications for Therapy of Hair Disorders.
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DOI：
10.2340/00015555-2843
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发表时间：
2018
影响因子：
3.6
通讯作者：
Xue-gang Xu;Hong-Duo Chen
中科院分区：
文献类型：
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作者：
Xue-gang Xu;Hong-Duo Chen
类前列腺素，包括前列腺素（pg）和血栓素A2 (TXA2)，是一类脂质衍生的类自身激素，可调节许多生理系统和病理环境。类前列腺素是由花生四烯酸在环加氧酶的催化下顺序代谢生成PGH2，然后在其特定合酶的催化下转化为PGD2、PGE2、PGF2α、PGI2和TXA2。最近的证据表明，前列腺素在调节头发生长中起作用。PGF2α类似物是美国食品和药物管理局批准的，通常用于促进人类睫毛的生长。据报道，PGE2可以保护小鼠免受辐射引起的脱发。相反，PGD2抑制头发生长。本文综述了前列腺素在毛囊中的代谢和前列腺素受体的表达模式，重点介绍了它们对头发生长的不同和相反的作用及其潜在机制。这在治疗和预防头发疾病方面具有潜在的临床意义。
Prostanoids, including prostaglandins (PGs) and thromboxane A2 (TXA2), are a family of lipid-derived autacoids that modulate many physiological systems and pathological contexts. Prostanoids are generated by sequential metabolism of arachidonic acid, catalysed by cyclo-oxygenase, to PGH2, which is then converted to PGD2, PGE2, PGF2α, PGI2 and TXA2, catalysed by their specific synthases. Recent evidence suggests that prostanoids play a role in regulating hair growth. The PGF2α analogue is Food and Drug Administration-approved in the US and routinely used to enhance the growth of human eyelashes. PGE2 is reported to protect from radiation-induced hair loss in mice. Conversely, PGD2 inhibits hair growth. This paper reviews the metabolism of prostanoids and the expression pattern of prostanoid receptors in hair follicles, focussing on their different and opposing effects on hair growth and the underlying mechanisms. This has potential clinical relevance in the treatment and prevention of hair disorders.