Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.

Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.
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DOI:
10.1039/b920680a
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发表时间:
2010-02-14
期刊:
Chemical communications (Cambridge, England)
影响因子:
--
通讯作者:
Balasubramanian S
Balasubramanian S
中科院分区:
其他
文献类型:
--
作者:
Fegan A;Shirude PS;Ying L;Balasubramanian S

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FRET 分析已用于检查源自 c-kit 原癌基因启动子序列的两个 DNA G 四链体(c-kit 1 和 c-kit 2)的折叠构象和不同的动力学稳定性。
FRET analysis has been used to examine the folded conformations and differing kinetic stabilities of two DNA G-quadruplexes (c-kit 1 and c-kit 2) derived from sequences found in the promoter of the c-kit proto-oncogene.
TrisubStttestated的异丙恶唑作为新的G四链体结合配体:C-KIT癌基因表达的小分子调节。
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