Elution and mechanical properties of antifungal bone cement
Elution and mechanical properties of antifungal bone cement
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DOI：
10.1016/j.arth.2006.09.013
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发表时间：
2007-09-01
影响因子：
3.5
通讯作者：
Crawford, Ross
中科院分区：
文献类型：
--
作者：
Goss, Ben;Lutton, Cameron;Crawford, Ross
考察了骨水泥中掺入两性霉素B的效果；正如文献表明的，这可能是治疗假体周围真菌感染的可行方法。添加抗真菌剂可提高骨水泥的抗压强度，从 107 +/- 2.3 MPa 增加到 121 +/- 1.5 MPa，具有统计学意义。使用紫外-可见光谱对妥布霉素和两性霉素 B 的洗脱进行定量。光谱显示，18% 的抗生素在第一周内释放，其中大部分在前 24 小时内释放。然而，1周后无法检测到抗真菌剂的洗脱，释放量不到0.03%。两性霉素 B 不会削弱骨水泥。它无法以临床上有效的剂量输送，因此没有明确的迹象表明将其掺入水泥中。
The effect of the incorporation of amphotericin B into bone cement was examined; as literature suggests, this may be a feasible method for the treatment of periprosthetic fungal infections. Addition of antifungal increased the compressive strength of the bone cement-a statistically significant amount from 107 +/- 2.3 to 121 +/- 1.5 MPa. Elution of tobramycin and amphotericin B was quantified using ultraviolet-visible spectroscopy. Spectroscopy showed that 18% of the antibiotic was released during the first week, with most released in the first 24 hours. The elution of antifungal, however, was unable to be detected after 1 week, with less than 0.03% released. Amphotericin B does not weaken bone cement. Its inability to be delivered at a clinically significant dose gives no clear indication for its incorporation into cement.