Fabrication and characterization of bioactive wollastonite/PHBV composite scaffolds
Fabrication and characterization of bioactive wollastonite/PHBV composite scaffolds
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DOI：
10.1016/j.biomaterials.2003.12.052
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发表时间：
2004-11-01
期刊：
影响因子：
14
通讯作者：
Chang, J
中科院分区：
文献类型：
--
作者：
Li, HY;Chang, J
采用模压成型、热处理和盐颗粒浸提法制备了聚羟基丁酸-聚羟基戊酸酯（PHBV）与生物活性硅灰石的复合支架。测定支架的结构和力学性能。通过模拟体液（SBF）浸泡评价复合材料的生物活性，并通过扫描电子显微镜（SEM）和能谱仪（EDS）分析羟基磷灰石（HAp）层的形成。结果表明，硅灰石/PHBV复合材料在模拟体液中浸泡14 d后，可诱导HA p在复合支架表面形成，具有生物活性。水接触角的测定结果表明，硅灰石的加入可以提高复合材料的亲水性，且其亲水性的提高程度与硅灰石的含量有关。此外，pH值和离子浓度的变化与复合支架的SBF溶液表明，复合材料释放的Ca和Si离子，这可以中和的酸性副产物的PHBV和稳定的pH值的SBF溶液在7.2和7.8之间的3周浸泡期。所有这些结果表明，硅灰石的掺入是一种有用的方法，以获得具有改善的性能的复合支架。(C)2003爱思唯尔有限公司。保留所有权利。
Composite scaffolds of polyhydroxybutyrate-polyhydroxyvalerate (PHBV) with bioactive wollastonite were fabricated by a compression moulding, thermal processing, and salt particulate leaching method. Structure and mechanical properties of the scaffolds were determined. The bioactivity of the composites was evaluated by soaking in a simulated body fluid (SBF), and the formation of the hydroxyapatite (HAp) layer was determined by Scanning Electron Microscope (SEM) and Energy-Dispersive Spectrometer (EDS). The results showed that the wollastonite/PHBV composites were bioactive as it induced the formation of HAp on the surface of the composite scaffolds after soaking in SBF for 14 days. In addition, the measurements of the water contact angles suggested that incorporation of wollastonite into PHBV could improve the hydrophilicity of the composites and the enhancement was dependent on the wollastonite content. Furthermore, the pH and ion concentration changes of SBF solutions with composite scaffolds showed that the composites released Ca and Si ions, which could neutralize the acidic by-products of the PHBV and stabilize the pH of the SBF solutions between 7.2 and 7.8 within a 3-week soaking period. All of these results suggest that the incorporation of wollastonite was a useful approach to obtain composite scaffolds with improved properties. (C) 2003 Elsevier Ltd. All rights reserved.