Cardiac function and disease: emerging role of small ubiquitin-related modifier.

Cardiac function and disease: emerging role of small ubiquitin-related modifier.
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DOI:
10.1002/wsbm.130
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发表时间:
2011-07
影响因子:
7.9
通讯作者:
Wang, Jun
Wang, Jun
中科院分区:
医学3区
文献类型:
--
作者:
Wang, Jun

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小的泛素相关修饰物,或SUMO,已经成为许多生物功能的多功能调节剂,通过酶促反应共价连接到各种底物上。SUMO结合也已被证明参与许多人类致病过程。SUMO领域的最新进展表明SUMO结合途径在心脏发生中的潜在作用。本文综述了SUMO结合途径的基本特征,并对SUMO结合途径在生理和病理条件下对心脏功能的影响进行了综述。
Small ubiquitin-related modifiers, or SUMOs, have emerged as versatile regulators of many biological functions that do so by covalent attachment to a variety of substrates via enzymatic reactions. SUMO conjugation has also been shown to be involved in a number of human pathogenic processes. More recent advances in the SUMO field have indicated a potential role for SUMO conjugation pathway in cardiogenesis. This advanced review will describe the basic features of the SUMO conjugation pathway and will summarize the most recent studies implicating the influence of the sumoylation pathway in cardiac function under both physiological and pathological conditions.
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