RESTRICTED LATERAL DIFFUSION OF PH-20, A PI-ANCHORED SPERM MEMBRANE-PROTEIN
RESTRICTED LATERAL DIFFUSION OF PH-20, A PI-ANCHORED SPERM MEMBRANE-PROTEIN
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DOI：
10.1126/science.3381102
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发表时间：
1988-06-24
期刊：
影响因子：
56.9
通讯作者：
MYLES, DG
中科院分区：
文献类型：
--
作者：
PHELPS, BM;PRIMAKOFF, P;MYLES, DG
The rate of lateral diffusion of integral membrane proteins is constrained in cells, but the constraining factors for most membrane proteins have not been defined. PH-20, a sperm surface protein involved in sperm-egg adhesion, was shown to be anchored in the plasma membrane by attachment to the lipid phosphatidylinositol and to have a diffusion rate that is highly restricted to testicular sperm, being more than a thousand times slower than lipid diffusion. These results support the hypothesis that lateral mobility of a membrane protein can be regulated exclusively by interactions of its ectodomain.
