Silver-Catalyzed Enantioselective Desymmetrization: Facile Access to Spirolactone-Pyrrolidines Containing a Spiro Quaternary Stereogenic Center
Silver-Catalyzed Enantioselective Desymmetrization: Facile Access to Spirolactone-Pyrrolidines Containing a Spiro Quaternary Stereogenic Center
复制标题
银催化的对映选择性去对称化：轻松获得含有螺四元立构中心的螺内酯-吡咯烷
DOI：
10.1021/ol400821q
复制
发表时间：
2013-05-03
期刊：
影响因子：
5.2
通讯作者：
Wang, Chun-Jiang
中科院分区：
文献类型：
--
作者：
Liu, Kang;Teng, Huai-Long;Wang, Chun-Jiang
一种前所未有的 Ag(I) 催化的螺环己二烯酮内酯不对称去对称反应已经成功开发出来，它在广泛的底物范围内表现良好，并提供了一种以高产率、优异的非对映/对映选择性轻松获得光学活性螺内酯-吡咯烷的方法。
An unprecedented Ag(I)-catalyzed asymmetric desymmetrization of Spiro cyclohexadienone lactones has been developed successfully, which performs well over a broad scope of substrates and provides a facile access to optically active spirolactone-pyrrolidines in high yields with excellent levels of diastereo-/enantioselectivities.