Relative impact of smoking and reduced pulmonary function on peptic ulcer risk. A prospective study of Japanese men in Hawaii.
Relative impact of smoking and reduced pulmonary function on peptic ulcer risk. A prospective study of Japanese men in Hawaii.
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吸烟和肺功能降低对消化性溃疡风险的相对影响。
DOI：
10.1016/0016-5085(89)90507-6
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发表时间：
1989
期刊：
影响因子：
29.4
通讯作者：
MacLean,CJ
中科院分区：
文献类型：
--
作者：
Stemmermann,GN;Marcus,EB;Buist,AS;MacLean,CJ
本研究的目的是确定肺功能降低是否是消化性溃疡的独立危险因素。在夏威夷研究的5933名日本男性中，243人在1968年完成检查后20年发生胃溃疡，99人发生十二指肠溃疡。检查包括测量1秒用力呼气量和详细的吸烟史。预测用力呼气量百分比与溃疡发生率呈显著负相关，但在调整吸烟或从不吸烟的人群中不相关。香烟与胃和十二指肠溃疡风险增加有关，但仅对胃溃疡显示出剂量反应。我们的结论是，在夏威夷的日本人的肺功能下降与消化性溃疡的关联主要归因于吸烟，吸烟与胃溃疡的关系比与十二指肠溃疡的关系更密切。香烟和胃溃疡之间的联系特别强，这表明吸烟减少或香烟焦油含量同步减少可能导致了最近男性胃溃疡的原因不明的减少。
The aim of this study was to determine whether reduced pulmonary function is an independent risk factor for peptic ulcer. Among 5933 Japanese men studied in Hawaii, 243 developed gastric ulcers and 99 developed duodenal ulcers 20 yr after an examination completed in 1968. The examination included measurement of forced expiratory volume in 1 s and a detailed smoking history. The percent predicted forced expiratory volume was significantly and inversely related to ulcer incidence, but not after adjustment for smoking or among those who had never smoked. Cigarettes were associated with increased ulcer risk in both stomach and duodenum but showed a dose-response in pack years only for gastric ulcer. We conclude that the association of reduced pulmonary function with peptic ulcer in the Japanese in Hawaii is largely attributable to smoking and that smoking is more strongly related to gastric than duodenal ulcer. The especially strong link between cigarettes and gastric ulcer suggests that decreased smoking or synchronous decrease in cigarette tar content may have contributed to the recent unexplained decrease in male gastric ulcer.