Adrenal 4-binding protein in common epithelial and metastatic tumors of the ovary
Adrenal 4-binding protein in common epithelial and metastatic tumors of the ovary
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DOI：
10.1016/s0046-8177(96)90168-9
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发表时间：
1996-06-01
期刊：
影响因子：
3.3
通讯作者：
Nagura, H
中科院分区：
文献类型：
--
作者：
Sasano, H;Kaga, K;Nagura, H
肾上腺4结合蛋白（Ad4BP）是一种调节类固醇生成酶表达的转录因子。性索间质肿瘤以外的卵巢肿瘤偶尔与功能性间质或激素异常有关。为了确定这些肿瘤的类固醇生成潜力，作者确定了75例原发性常见上皮性肿瘤（20例囊腺瘤，15例低恶性潜能癌和40例癌）和7例卵巢转移癌患者中Ad4BP的免疫组化分布。在15例低度恶性潜能癌中的3例（20%）、40例癌中的26例（65%）和7例转移癌中的3例（43%）中，在瘤内基质细胞中观察到Ad4BP免疫反应性。Ad4BP在囊腺瘤间质中未见阳性表达。在阳性病例中，Ad4BP阳性基质细胞特别分布于浸润性癌腺附近。在卵巢癌中，粘液癌显示出显着较高的Ad4BP阳性的瘤内基质细胞的数量比其他组织学类型。结果提示，原发癌或转移癌侵袭卵巢间质，特别是转移癌，可使间质细胞获得代谢和合成类固醇激素的潜能。版权所有（C）1996由W.B.桑德斯公司
Adrenal 4-binding protein (Ad4BP) is a transcription factor that regulates the expression of steroidogenic enzymes. Ovarian tumors other than sex cord stromal tumors are occasionally associated with functioning stroma or hormonal abnormalities. To determine the steroidogenic potential of these tumors, the authors determined the immunohistochemical distribution of Ad4BP in 75 patients with primary common epithelial tumors (20 cystadenomas, 15 carcinomas of low malignant potential, and 40 carcinomas), and seven patients with metastatic carcinoma of the ovary. Ad4BP immunoreactivity was observed in intratumoral stromal cells in 3 of 15 (20%) carcinomas of low malignant potential, 26 of 40 (65%) carcinomas, and three of seven (43%) metastatic carcinomas. Ad4BP immunoreactivity was not observed in the stroma of cystadenomas. Among the positive cases, Ad4BP-positive stromal cells were particularly distributed adjacent to invasive carcinomatous glands. Among ovarian carcinomas, mucinous carcinoma showed a significantly higher number of Ad4BP-positive intratumoral stromal cells than did other histological types. Results suggest that invasion of primary or metastatic carcinoma into the ovarian stroma, especial in the Ease of mutinous carcinoma, may render the stromal cells to acquire the potential of metabolizing and synthesizing steroid hormones. Copyright (C) 1996 by W.B. Saunders Company